Columbia, MONCT06335771Now EnrollingIRB Ready

Obesity Clinical Trial in Columbia, MO

Access cutting-edge obesity treatment through this clinical trial at a research site in Columbia. Study-provided care at no cost to qualified participants.

Sponsored by Bettina Mittendorfer

Quick Self-Assessment

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Expert Care in Columbia

Access obesity specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related obesity treatment provided free

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Check if you qualify for this obesity clinical trial in Columbia, MO

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Columbia

    Convenient for MO residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Columbia site if eligible
  4. 4Begin participation

About This Obesity Study in Columbia

The goal of this study is to evaluate the role of transcription factor EB (TFEB) in adipose (fat) tissue macrophages (ATM) in regulating adipose tissue and systemic metabolic function in obesity. The investigators will assess the differences in ATM lipid metabolism in people with metabolically abnormal obesity and lean individuals. Both groups will have: * screening visit * imaging (body composition testing - dual-energy x-ray absorptiometry (DEXA) scans, magnetic resonance imaging \[MRI\] and magnetic resonance spectroscopy \[MRS\] scans) * Overnight visit with intravenous infusion (IV), muscle, and fat tissue biopsies Participants with obesity will complete meetings with study team members for a weight loss intervention to achieve a 10% body weight loss.

Sponsor: Bettina Mittendorfer

Who Can Participate

Inclusion Criteria

age: ≥18 but ≤70 years
not pregnant or breastfeeding
weight stable and sedentary before enrollment
no use tobacco products, excessive amounts of alcohol, or dietary supplements, or medications known to or suspected to affect glucose and lipid metabolism (aside from certain medications used to treat diabetes in the metabolically abnormal obesity \[MAO\]-Type 2 Diabetes group)
no evidence of significant organ system dysfunction or disease (e.g. chronic severe kidney disease, cancer)
participants must fulfil all of the following group-specific inclusion criteria below: Lean group:
Body mass index (BMI) ≥18.5 but \<25.0 kg/m2
Intrahepatic triglyceride (IHTG) content \<5%
fasting blood glucose concentration: \<100 mg/dl
blood glucose concentration 2 h after a 75 g oral glucose challenge: \<140 mg/dl
Hemoglobin A1C (HbA1c) \<5.7 % Metabolically normal obesity (MNO) group:
BMI ≥30.0 but \<45.0 kg/m2
IHTG content \<5%
fasting blood glucose concentration: \<100 mg/dl
blood glucose concentration 2 h after a 75 g oral glucose challenge: \<140 mg/dl
HbA1c \<5.7 % Metabolically abnormal obesity (MAO)-insulin resistance and non-alcoholic fatty liver disease (NAFLD) group:
BMI ≥30.0 but \<45.0 kg/m2
IHTG content \>7.5%
fasting blood glucose concentration: ≥100 but \<126 mg/dl
blood glucose concentration 2 h after a 75 g oral glucose challenge: ≥140 but \<200 mg/dl
HbA1c: ≥5.7 but \<6.4 % MAO-type 2 diabetes group:
BMI ≥30.0 but \<45.0 kg/m2
clinical diagnosis of type 2 diabetes or fasting blood glucose concentration \>126 mg/dl or blood glucose concentration 2 h after a 75 g oral glucose challenge\>200 mg/dl or HbA1c \>6.4 % without medication if not diagnosed and medically treated for diabetes

Exclusion Criteria

\- Individuals that do not meet all inclusion Criterion

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Columbia?

Yes, this clinical trial (NCT06335771) has an active research site in Columbia, MO that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Obesity Treatment Options in Columbia, MO

If you're searching for obesity treatment options in Columbia, MO, this clinical trial (NCT06335771) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Columbia research site is actively enrolling participants for this clinical trial. You'll receive care from experienced obesity specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all obesity clinical trials near you to find additional studies recruiting in your area.

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