Orange, CANCT05975580Now EnrollingIRB Ready

Obesity Clinical Trial in Orange, CA

Access cutting-edge obesity treatment through this clinical trial at a research site in Orange. Study-provided care at no cost to qualified participants.

Sponsored by University of California, Irvine

Quick Self-Assessment

See if you qualify for this Orange location

Preparing your pre-screening questions…

Expert Care in Orange

Access obesity specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related obesity treatment provided free

Apply for This Orange Location

Check if you qualify for this obesity clinical trial in Orange, CA

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Orange

    Convenient for CA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Orange site if eligible
  4. 4Begin participation

About This Obesity Study in Orange

This is a randomized controlled trial employing a Sequential Multiple Assignment Randomized Trial (SMART) design to test whether pharmacotherapy, in conjunction with lifestyle counseling, can reverse weight regain after bariatric surgery.

Sponsor: University of California, Irvine

Who Can Participate

Inclusion Criteria

Male and female subjects aged 18-70 years
Had sleeve gastrectomy (SG) or Roux-en-Y gastric bypass (RYGB) at least 18 months ago
Weight regain of ≥5% relative to post-surgery nadir weight
Body mass index (BMI) ≥30 kg/m2 or ≥27 kg/m2 with weight-related comorbidities
Women of childbearing potential must be using appropriate contraception to avoid pregnancy throughout the study, and must have a negative pregnancy test at study entry
Must be able to provide written informed consent

Exclusion Criteria

Type 1 diabetes
Insulin-dependent type 2 diabetes
Fasting plasma glucose (FPG) ≥240 mg/dL
Uncontrolled hypertension defined as systolic blood pressure (SBP) ≥150 mm Hg and/or diastolic blood pressure (DBP) ≥100 mm Hg on the average of three seated measurements after being at rest for at least 5 minutes
History of significant (as determined by the investigator) and unstable cardiovascular disease including coronary artery disease, arrhythmias, severe congestive heart failure, or stroke
Use of monoamine oxidase inhibitors, current or within 2 weeks
Hyperthyroidism or other significant thyroid disease
Angle-closure glaucoma
Agitated states
History of drug abuse within the past year
Known hypersensitivity or idiosyncrasy to sympathomimetic amines
Severe hepatic disease (non-alcoholic fatty liver disease or non-alcoholic steatohepatitis without portal hypertension or cirrhosis is acceptable)
End-stage renal disease
History of nephrolithiasis
Serum triglycerides ≥500 mg/dL
Cancer, not in remission, within the past 2 years except for adequately treated basal cell, squamous cell skin cancer, or in-situ cervical cancer
History of psychosis or bipolar disorder
Suicidal ideation or unstable/untreated major depressive disorder within the past year
Use of antidepressant medication that has not been at stable dose for at least 3 months
Hospital Anxiety and Depression Scale (HADS) score of ≥11 for depression or anxiety items
Binge Eating Scale (BES) score of ≥27
Alcohol use disorder within the past year
Currently taking phentermine or topiramate or the combination, or products containing these drugs
Currently taking stimulants (e.g., Attention Deficit Hyperactivity Disorder medications)
Current use of prescription or over-the-counter weight loss drugs or supplements
Taking prescription or over-the-counter drugs or products, which in the opinion of the PI, could be associated with significant effects on body weight
Planning additional bariatric surgery procedures in the next 13 months
History of revisional bariatric surgery (revisional surgery after adjustable gastric banding is acceptable)
Currently participating in another weight loss program or have plans to participate in the next 13 months
Smoking cessation within the previous 3 months or plans to quit smoking in the next 13 months
Pregnant or breastfeeding or planning pregnancy in the coming 13 months
History of, or any existing condition that, in the opinion of the Principal Investigator, would interfere with the study outcomes or place the subject at unacceptable risk by participating in the study

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Orange?

Yes, this clinical trial (NCT05975580) has an active research site in Orange, CA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Obesity Treatment Options in Orange, CA

If you're searching for obesity treatment options in Orange, CA, this clinical trial (NCT05975580) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Orange research site is actively enrolling participants for this clinical trial. You'll receive care from experienced obesity specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all obesity clinical trials near you to find additional studies recruiting in your area.

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Secure · Expert Care · Orange, CA