NCT07518407 · University of South Carolina
Dietary Insights and Nutritional Education in Adults on GLP-1 Therapy
(DINE-GLP1)
What this study is about
This pilot study will evaluate the feasibility, acceptability, and perceived usefulness of the SWITCH mobile nutrition behavioral intervention among adults receiving GLP-1 receptor agonist therapy for obesity and/or type 2 diabetes.
View original scientific description
This pilot study will evaluate the feasibility, acceptability, and perceived usefulness of the SWITCH mobile nutrition behavioral intervention among adults receiving GLP-1 receptor agonist therapy for obesity and/or type 2 diabetes. Participants will complete baseline assessments, receive a 6-week app-based nutrition intervention consisting of daily dietary self-monitoring and weekly learning modules, and complete follow-up assessments and a structured interview.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- • Age between 18 and 65 years.
- BMI between 30 - 49.9 kg/m2 and/or diagnosed with type 2 diabetes.
- Currently prescribed and using GLP-1 receptor therapy for at least 4 weeks.
- Own a smartphone (Android or iOS) with an active data plan to support app-based intervention delivery.
- Residing anywhere in the United States.
- Must be willing and able to reduce caloric intake.
- Be free of major health or psychiatric diseases, drug, or alcohol dependency.
- Willing to sign informed consent.
Exclusion criteria
- • Presence of type 1 diabetes mellitus
- Severe complications, including but not limited to proliferative retinopathy, severe peripheral neuropathy, nephropathy requiring dialysis, active foot ulcers, or recent hospitalization for diabetic ketoacidosis or hyperosmolar hyperglycemic state within the past 6 months.
- Current or recent (within 6 months) participation in another structured weight loss program or clinical trial that may interfere with study outcomes.
- Pregnancy, breastfeeding, or plans to become pregnant during the study period.
- Current use of another investigational weight loss device or medication.
- Diagnosed eating disorders (e.g., anorexia nervosa, bulimia nervosa, binge eating disorder) or other psychiatric conditions that may affect adherence to behavioral interventions, as determined by study staff.
- Severe cardiovascular, hepatic, renal, or pulmonary disease that would limit participation in moderate physical activity or dietary modification.
- Active cancer treatment (chemotherapy, radiation, or surgery) within the past 12 months.
- Substance use disorder or alcohol dependency within the past 12 months.
- Cognitive impairment or any medical or mental condition that would interfere with the ability to understand or comply with study procedures.
- Lack of reliable internet or smartphone access, or unwillingness to use a mobile app for tracking and communication.
Where
- Columbia, South Carolina
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jun 12, 2026 · Source of record for eligibility and locations