NCT05359562 · University of Pennsylvania
How Hormones and Exposure and Response Prevention (EX/RP) Affect the Brain of People With OCD
What this study is about
Studies show that hormones affect the brain's fear extinction network, which is relevant for therapy involving exposure and response prevention (EX/RP), a first-line treatment for obsessive compulsive disorder (OCD).
View original scientific description
Studies show that hormones affect the brain's fear extinction network, which is relevant for therapy involving exposure and response prevention (EX/RP), a first-line treatment for obsessive compulsive disorder (OCD). This study will examine the effect of delivering EX/RP to women during different phases in their menstrual cycle to determine the effects of hormones on the fear extinction network and on their OCD symptoms.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Diagnostic and Statistical Manual of Mental Disorders (DSM-5) Diagnosis of OCD;
- Male and female subjects aged between 18- 45;
- Women must be menstruating and regularly cycling
- Ability to tolerate a treatment-free period;
- No psychotropic medication in the past 12 weeks
- At entry, at least moderate severity OCD
- Willingness and ability to give written informed consent after full explanation of study procedures.
Exclusion criteria
- Use of birth control (oral contraception or IUD) that affects the menstrual cycle, or menopause.
- Pregnancy. Women of childbearing potential will be required to sign a statement indicating their intention to avoid pregnancy during the study.
- Neurologic or medical condition that would prevent safe participation in the full study protocol.
- Any contradiction to magnetic resonance imaging (e.g., metallic implants or devices).
- Comorbid psychiatric conditions that significantly elevate the risks associated with study participation or confound results.
- Patients with prominent suicidal ideation or with a recent suicide attempt.
- Current psychotherapy
Where
- New York, New York
- Philadelphia, Pennsylvania
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jun 22, 2026 · Source of record for eligibility and locations