NCT07804446 · University of Chicago
Patient Pain and Function in Medial Knee Osteoarthritis After Anteromedial vs Anterolateral Intra-Articular Corticosteroid Injection
(Medial OA CSI)
What this study is about
The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee. Participants will: 1. Be randomly divided into getting their steroid injection on the inside or outside of their knee. 2.
View original scientific description
The primary purpose of this study is to find out if there is a difference in pain experienced in patients with knee arthritis of the inside of their knee if they get a steroid injection on the inside or outside of their knee. Participants will: 1. Be randomly divided into getting their steroid injection on the inside or outside of their knee. 2. Answer a pain survey before their injection as well as over the phone 2 weeks, 6 weeks, and 12 weeks after their injection.
Interventions
PROCEDURE
Anteromedial Injection
If randomized to this intervention, patients will receive a corticosteroid injection in the anteromedial side of their knee.
PROCEDURE
Anterolateral Injection
If randomized to this intervention, patients will receive a corticosteroid injection on the anterolateral side of their knee.
Primary outcome measures
Numeric Pain Rating Scale
Time frame: Pre-procedure, 2 weeks, 6 weeks, and 12 weeks post-injection
This survey asks patients to rate their pain on a scale from 0 to 10.
Knee Osteoarthritis and Outcome Score-Joint Replacement
Time frame: Pre-procedure, 2 weeks, 6 weeks, and 12 weeks post-injection
This standardized survey asks patients to describe the impact of their knee stiffness and pain on daily tasks.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Clinical diagnosis of knee OA with predominant medial compartment symptoms
- Radiographic moderate-to-severe medial compartment OA (KL grade 3-4 or equivalent)
- Agreed to and preparing to receive a CSI of the knee as part of standard care from surgeon, regardless of past injection of the knee
- Able to provide informed consent
- Able to complete phone, email, or MyChart follow-ups in English
Exclusion criteria
- Predominant lateral compartment OA or patellofemoral-only OA
- Inflammatory arthritis (RA, gout flare, etc.)
- Suspected or confirmed joint infection or overlying cellulitis
- Prior knee arthroplasty on the index knee
- Planned surgery for index knee within 12-week follow-up
- Inability to complete follow-up assessments
- Other clinician-determined contraindication to CSI
Where
- Bolingbrook, Illinois
- Chicago, Illinois
- La Grange, Illinois
- Orland Park, Illinois
- Woodridge, Illinois
Collaborators
AdventHealth
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Sep 4, 2026 · Source of record for eligibility and locations