Palo Alto, CANCT05700682Now EnrollingIRB Ready

Osteoarthritis, Knee Clinical Trial in Palo Alto, CA

Access cutting-edge osteoarthritis, knee treatment through this clinical trial at a research site in Palo Alto. Study-provided care at no cost to qualified participants.

Sponsored by Palo Alto Veterans Institute for Research

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Expert Care in Palo Alto

Access osteoarthritis, knee specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related osteoarthritis, knee treatment provided free

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Check if you qualify for this osteoarthritis, knee clinical trial in Palo Alto, CA

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Why Participate?

  • No-Cost Study Care

  • Local to Palo Alto

    Convenient for CA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Palo Alto site if eligible
  4. 4Begin participation

About This Osteoarthritis, Knee Study in Palo Alto

In this work the investigators will study the relationship between chronic musculoskeletal pain and abnormal blood flow (neovascularity) around the shoulder, hip and knee. Veterans with as history of chronic shoulder, hip or knee pain and mild/moderate joint degenerative changes will be potential study subjects. Blood flow around joints will be evaluated using perfusion magnetic resonance imaging (MRI). Participants with demonstrably abnormal blood flow around their painful joint will be eligible for enrollment in a pilot study of joint embolization to treat their pain. Participants who choose to not undergo treatment will be re-assessed with MRI after one year to characterize the natural history of joint neovascularity and its relationship to pain.

Sponsor: Palo Alto Veterans Institute for Research

Who Can Participate

Inclusion Criteria

(Both Arms):
Participants must be Veterans who receive care in the VA system.
Participants must have a history of chronic pain of the shoulder, hip or knee for at least 1 year.
Participants must have mild to moderate degenerative changes of the painful joint as depicted on prior imaging (X-ray, CT or MRI).
Participants must have undergone at least one failed primary treatment for their chronic pain (e.g. physical therapy, NSAIDs, steroid injection).
Participants must have an MRI of their painful joint (shoulder, hip or knee) ordered by a clinical provider. Inclusion Criteria (Therapeutic Arm):
Participants must have enrolled in the Diagnostic Arm of the study and must have undergone perfusion MR imaging of their painful joint.
Participants must have evidence of peri-articular hypervascularity on their perfusion MR exams. This will be determined by the study PIs.

Exclusion Criteria

(Diagnostic Arm):
Acute injury in the last 12 weeks.
Age under 25.
Severe degenerative changes of painful joint (shoulder, hip or knee).
History of arthroplasty or metallic implant within the painful joint.
Severe gadolinium contrast allergy.
Severe renal disease or ongoing dialysis.
History of malignancy with life expectancy of less than one year, or malignancy with known bone metastasis.
Current pregnancy.
Formal diagnosis of cognitive impairment. Exclusion Criteria (Therapeutic Arm):
Severe iodinated contrast allergy.
Severe coronary or peripheral arterial disease.
Coagulopathy.
Uncontrolled type 2 diabetes or diabetic neuropathy.
History of seizures or other severe complication from conscious sedation.
Prior upper or lower extremity arterial bypass.
Ongoing participation in another interventional (therapeutic) trial for chronic joint pain.
Lack of peri-articular hypervascularity on initial perfusion MRI.
All exclusion criteria for the Diagnostic Arm.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Palo Alto?

Yes, this clinical trial (NCT05700682) has an active research site in Palo Alto, CA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Osteoarthritis, Knee Treatment Options in Palo Alto, CA

If you're searching for osteoarthritis, knee treatment options in Palo Alto, CA, this clinical trial (NCT05700682) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Palo Alto research site is actively enrolling participants for this clinical trial. You'll receive care from experienced osteoarthritis, knee specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all osteoarthritis, knee clinical trials near you to find additional studies recruiting in your area.

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