Chevy Chase, MDNCT06488313Now EnrollingIRB Ready

OTC Deficiency Clinical Trial in Chevy Chase, MD

Access cutting-edge otc deficiency treatment through this phase 2 clinical trial at a research site in Chevy Chase. Study-provided care at no cost to qualified participants.

Sponsored by Arcturus Therapeutics, Inc.

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Expert Care in Chevy Chase

Access otc deficiency specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related otc deficiency treatment provided free

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Check if you qualify for this otc deficiency clinical trial in Chevy Chase, MD

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Why Participate?

  • No-Cost Study Care

  • Local to Chevy Chase

    Convenient for MD residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Chevy Chase site if eligible
  4. 4Begin participation

About This OTC Deficiency Study in Chevy Chase

Evaluate the safety and pharmacodynamics of multiple doses of ARCT-810 in adolescent and adult participants with OTC deficiency.

Sponsor: Arcturus Therapeutics, Inc.

Who Can Participate

Inclusion Criteria

Willingness and ability to comply with all the protocol requirements, complete all study visits and sign informed consent.
Males and Females aged ≥12 years, at Screening.
Documented clinical diagnosis of OTC deficiency.
History of symptomatic hyperammonemia or elevated plasma ammonia or glutamine with clinical stability for at least 1 month prior to Screening.
Medically managed for OTC deficiency and receiving a stable protein-restricted diet, dietary supplements, and/or ammonia scavenger regimen (if applicable) for at least 28 days.
Good general health with no clinically significant abnormal findings that would interfere with study procedures (including plasma ammonia within participant's historical range).
Must be willing to adhere to contraception guidelines.

Exclusion Criteria

Uncontrolled hypertension.
Symptoms of infection for at least 7 days prior to dosing.
Malignancy within 5 years, except for basal or squamous cell carcinoma of the skin or carcinoma in situ of the cervix that has been successfully treated.
History of any OTC gene therapy, or history of liver-derived stem cell therapy in the past 2 years.
History of any organ transplant.
History of severe allergic reaction to a liposomal or PEG-containing product.
History of congenital or acquired cardiac disorders.
Abuse of medications, illicit drugs or alcohol.
Blood donation of 50 to 499 mL within 30 days of screening or of \>499 mL within 60 days of screening.
Clinically significant laboratory abnormalities on screening labs including INR \>1.5, eGFR\< 60 mL/min/1.73m2 or positive test results for HIV, HBV, or HCV.
Inadequately controlled diabetes.
Clinically significant anemia.
Changes in maintenance therapies for OTC deficiency with 28 days prior to dosing.
Medical history requiring continuous or intermittent systemic corticosteroid administration.
Receipt of inhibitors of urea synthesis or drugs that significantly affect renal clearance.
Recent treatment with another investigational drug, biological agent, or device.
Treatment with any oligonucleotide (siRNA or mRNA) within 6 months prior to screening. COVID-19 vaccines are not exclusionary.
Involved in study conduct or an immediate family member of an individual involved in the study.
Participated in another dosing cohort of the study.
Any other conditions, in the opinion of the investigator, that would interfere with participation.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Chevy Chase?

Yes, this clinical trial (NCT06488313) has an active research site in Chevy Chase, MD that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

OTC Deficiency Treatment Options in Chevy Chase, MD

If you're searching for otc deficiency treatment options in Chevy Chase, MD, this clinical trial (NCT06488313) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Chevy Chase research site is actively enrolling participants for this phase 2 clinical trial. You'll receive care from experienced otc deficiency specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all otc deficiency clinical trials near you to find additional studies recruiting in your area.

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