NCT07428187 · University of Colorado, Denver
Snacking Effects on the Brain Response to Foods and Satiety During Dieting
What this study is about
This study plans to learn more about how different types of snacks may affect brain processes relating to eating behaviors during a diet intervention.
View original scientific description
This study plans to learn more about how different types of snacks may affect brain processes relating to eating behaviors during a diet intervention.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- 25-45 years old
- BMI at least 27 kg/m2
- Comfortable completing a weight-loss intervention\\
- Willing to consume a daily snack of either walnuts or pretzels
Exclusion criteria
- Nut or wheat allergy
- History of bariatric surgery
- Current eating disorder
- Current illicit substance use
- Current pregnancy, lactation (or less than 3 months after stopping lactation), or less than 6 months postpartum
- Uncontrolled hypertension (\>160/100 mmHg)
- Significant endocrine/metabolic disease kidney disease, liver disease, or blood disease that would be anticipated to affect study results
- Taking injectable medications, sulfonylureas, or meglitinides for diabetes treatment
- Taking weight-loss medications, or steroids within \~3 months prior to study participation (e.g., GLP-1 receptor agonists)
- Significant mental health changes within \~3 months prior to study participation (e.g., medication adjustments, new psychiatric diagnoses, hospitalization relating to mental health concerns)
- Neurological illnesses or injury that would be anticipated to affect MRI data
- Weight change greater than 10% within 3 months prior to study participation
- Currently participating in another weight-loss study
- Not comfortable eating the study-provided meals (with allowances for dietary preferences) and/or following a highly restrictive diet (e.g., vegan)
- MRI-specific exclusion criteria (e.g., metal in the body, weight \>500 lbs
Where
- Aurora, Colorado
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Mar 23, 2026 · Source of record for eligibility and locations