NCT06271291 · Mayo Clinic
Pancreatic Cancer Detection Consortium (PCDC) Prospective Cohorts
What this study is about
This study evaluates individuals without pancreatic cancer, but who have been determined to be at higher-than-average lifetime risk of developing pancreatic cancer to help detect pancreatic cancer or other cancers at an earlier time when they might be more easily treated and cured.
View original scientific description
This study evaluates individuals without pancreatic cancer, but who have been determined to be at higher-than-average lifetime risk of developing pancreatic cancer to help detect pancreatic cancer or other cancers at an earlier time when they might be more easily treated and cured.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- PDAC FAMILY HISTORY OR PDAC RELATED GENETIC MUTATIONS:
- Age: 50 or older, plus at least one of the following:
- Mutation unknown or absent:
- 2+ relatives with PDAC on same side of family where 2 affected are first degree related to each other and at least 1 affected is first degree related to subject;
- OR 2+ affected first degree relatives \[(FDR), defined as blood related parents, siblings, or children\]
- Known pathogenic/likely pathogenic (P/LP) mutation in at least one of the following:
- CDKN2A/p16, Peutz-Jeghers syndrome (PJS) serine/threonine kinase 11 (STK11), Hereditary pancreatitis with confirmed protease serine 1 (PRSS1)
- OR 1+ or second degree relative (SDR) with PDAC and a known P/LP mutation in one or more of:
- ATM, BRCA1, BRCA2, PALB2, Lynch syndrome (MLH1, MSH2, MSH6, PMS2, EPCAM), TP53
- HIGH-RISK OR WORRISOME PANCREATIC CYSTS:
- 18 years of age or greater and meeting Fukuoka worrisome (FW) or Fukuoka high-risk (FHR) criteria
- High risk stigmata:
- Obstructive Jaundice in a patient with cystic lesion of the head of the pancreas
- Enhancing mural nodule ≥ 5 mm
- Main pancreatic duct ≥ 10 mm
- Worrisome features:
- Presence of pancreatic duct stricture, defined as focal pancreatic duct narrowing with upstream duct =\> 6 mm
- Cyst ≥ 3 cm
- Enhancing mural nodule \< 5 mm
- Thickened/Enhancing cyst wall
- Main duct size 5-9 mm
- Pancreatitis
- Lymphadenopathy
- Increased CA 19-9
- Cyst growth rate ≥ 5 mm /2 years
Exclusion criteria
- Is unable to provide informed consent
- Has received a non-autologous bone marrow transplant or has an active hematologic malignancy (i.e., leukemia or lymphoma)
- Current or prior history of PDAC or total pancreatectomy
- Is currently a prison inmate
- Is not able to speak or read English
Where
- Scottsdale, Arizona
- Atlanta, Georgia
- Peoria, Illinois
- Baltimore, Maryland
- Boston, Massachusetts
- Rochester, Minnesota
- Omaha, Nebraska
- Portland, Oregon
- Pittsburgh, Pennsylvania
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jun 1, 2026 · Source of record for eligibility and locations