Understanding Motivation in Parkinson's Patients Through Neurophysiology

OTHER

Stimulation on

Stimulation from Percept DBS will be on while the patient is playing a decision-making game on a computer-based application.

OTHER

Stimulation off

Stimulation from Percept DBS will be off while the patient is playing a decision-making game on a computer-based application.

BEHAVIORAL

Decision Making Task

Patients will be playing a decision making task through a computer-based application.

Percent of Risky Decisions made with Percept DBS stimulation on for Parkinson's Disease Patients

Time frame: The values will be collected starting from admission in clinic and the at-home paradigm. Data collection and analysis of said values can take up to three years

Patients' responses on the tablet will be recorded in-clinic and at home. The investigators will tally their choices from the value-based decision making game (risky versus safe decisions) and report an average of risky responses.

Percent of Risky Decisions made with Percept DBS stimulation off for Parkinson's Disease Patients

Time frame: The values will be collected starting from admission in clinic and the at-home paradigm. Data collection and analysis of said values can take up to three years

Patients' responses on the tablet will be recorded in-clinic and at home. The investigators will tally their choices from the value-based decision making game (risky versus safe decisions) and report an average of risky responses.

Reaction Time During Decision-Making Task

Time frame: The values will be collected starting from admission in clinic. Data collection and analysis of said values can take up to three years.

The investigators will measure the time it takes for patients to make each decision on the value-based decision-making task in the clinic.

Task Success Rate

Time frame: The values will be collected starting from admission in clinic. Data collection and analysis of said values can take up to three years.

The investigators will calculate the percentage of trials in which patients complete the task successfully according to predefined task performance criteria.

Acceptance Rate of Risky Versus Safe Options

Time frame: The values will be collected starting from admission in clinic. Data collection and analysis of said values can take up to three years.

The proportion of trials where patients accept risky versus safe options will be calculated and compared across stimulation ON and OFF conditions.

Force Exertion During Motor Responses

Time frame: The values will be collected starting from admission in clinic. Data collection and analysis of said values can take up to three years.

Force data will be recorded during motor responses to evaluate physical engagement and motor control during task performance.

Low frequency local field potentials

Time frame: The values will be collected starting from admission in clinic. Data collection and analysis of said values can take up to three years.

Local field potentials (LFPs) will be recorded from the implanted Percept device to evaluate neural activity during decision making under different stimulation conditions. Low frequency power will be calculated during specific time intervals during the task. Cardiac artifact will be removed with electrocardiogram (ECG) measurements recorded during the same task.

Electroencephalogram (EEG) theta band power

Time frame: The values will be collected starting from admission in clinic. Data collection and analysis of said values can take up to three years.

Scalp EEG will be recorded concurrently with task performance to assess cortical activity patterns during decision-making. Average theta band power will be calculated in specific time intervals during the task.

Electroencephalogram (EEG) beta band power

Time frame: The values will be collected starting from admission in clinic. Data collection and analysis of said values can take up to three years.

Scalp EEG will be recorded concurrently with task performance to assess cortical activity patterns during decision-making. Average beta band power will be calculated in specific time intervals during the task.

Electroencephalogram (EEG) gamma band power

Time frame: The values will be collected starting from admission in clinic. Data collection and analysis of said values can take up to three years.

Scalp EEG will be recorded concurrently with task performance to assess cortical activity patterns during decision-making. Average gamma band power will be calculated in specific time intervals during the task.

Electroencephalogram (EEG) alpha band power

Time frame: The values will be collected starting from admission in clinic. Data collection and analysis of said values can take up to three years.

Scalp EEG will be recorded concurrently with task performance to assess cortical activity patterns during decision-making. Average alpha band power will be calculated in specific time intervals during the task.

What is a clinical trial?

A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.

Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.

Will I be compensated?

Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.

Will I receive a placebo instead of treatment?

When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.

Can I leave a trial if I change my mind?

Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.

How long does a clinical trial last?

Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.