NCT06467695 · University of South Alabama
Low Voltage Electrical Stimulation for Depression in Parkinson's Patients
(LVESDIPP)
What this study is about
The goal of this clinical trial is to determine the relative effectiveness of fMRI model guided Transcranial Direct Current Stimulation (mgTDCS) in improving the depressive symptoms of patients with Parkinson's Disease (PD).
View original scientific description
The goal of this clinical trial is to determine the relative efficacy of fMRI model guided Transcranial Direct Current Stimulation (mgTDCS) in improving the depressive symptoms of patients with Parkinson's Disease (PD).
Interventions
DEVICE
BIOPAC Stimsola
Transcranial Electrical Stimulator
DEVICE
BIOPAC Stimsola Sham (zero amps)
Transcranial Electrical Stimulator set to 0 amps
Primary outcome measures
Beck Depression Inventory (BDI) Pre-post change score
Time frame: One at Day 1 and one after 15 sessions of training, typically 4 weeks after study start.
The BDI, a self-report measure for assessing depression, has high internal consistency (Cronbach's alpha \> .90) and good test-retest reliability.
Alpha band power pre-post change score
Time frame: One at Day 1 and one after 15 sessions of training, typically 4 weeks after study start.
Alpha band power from pre-post eeg records will be assessed for power changes at frontal sites.
RBANS Working Memory
Time frame: One at Day 1 and one after 15 sessions of training, typically 4 weeks after study start.
Digit Span and Story Memory subtests will be used to determine changes in working memory.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- 19 to 65 years in age.
- Parkinson's Group must have a physician dx of Parkinson's Disease
- Must meet exhibit elevated levels of depression on the Beck Depression Inventory (scores of 20 or above).
- Must be willing and able to travel of the Psychology Department for EEG and tDCS sessions.
- Participants who have undergone surgery for Deep Brain Stimulation implantation may be enrolled if advised to and monitored by their physician.
- Read and understand spoken English.
Exclusion criteria
- No history of or being treated for epilepsy or other seizure disorders.
- No history of penetrating head wounds or TBI greater than mild TBI.
- No history of atypical Parkinson's
Where
- Mobile, Alabama
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Apr 6, 2026 · Source of record for eligibility and locations