Charlestown, MANCT06098612Now EnrollingIRB Ready

Parkinson's Disease Clinical Trial in Charlestown, MA

Access cutting-edge parkinson's disease treatment through this early phase 1 clinical trial at a research site in Charlestown. Study-provided care at no cost to qualified participants.

Sponsored by Massachusetts General Hospital

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Expert Care in Charlestown

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IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related parkinson's disease treatment provided free

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Check if you qualify for this parkinson's disease clinical trial in Charlestown, MA

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Why Participate?

  • No-Cost Study Care

  • Local to Charlestown

    Convenient for MA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Charlestown site if eligible
  4. 4Begin participation

About This Parkinson's Disease Study in Charlestown

The overall goal of the proposed research is to evaluate the use of \[11C\]SY08 as a PET radiotracer for aggregated alpha synuclein (αS) in individuals with Parkinson's disease (PD), Multiple system atrophy (MSA), Dementia with Lewy Bodies (DLB) and healthy controls. The purpose of this study is to evaluate the use of \[11C\]SY08 as a PET radiotracer for αS fibrils in individuals with PD, MSA, DLB and healthy controls. The specific aims of the current study are: 1. To determine brain uptake, distribution, and kinetics of \[11C\]SY08 in healthy individuals. 2. To determine brain uptake, distribution, and kinetics of \[11C\]SY08 in patients with alpha synuclein aggregates in the brain, including PD, DLB and MSA. 3. To determine human dosimetry of \[11C\]SY08 in healthy individuals An intravenous bolus injection of \[11C\]SY08 will be administered per subject for brain PET imaging.

Sponsor: Massachusetts General Hospital

Who Can Participate

Inclusion Criteria

General Inclusion criteria, all subjects must:
Be able to provide written informed consent or assent
Be able to read, speak and understand English (The investigators do not have the resources necessary to properly study non-English speaking patients in this study, given that translation and validation of the assessment tools would be necessary)
Be willing and able to participate in one PET/MRI scanning session Additional Inclusion criteria for PD patients, subjects must:
Have an existing diagnosis of idiopathic PD, using consensus criteria
Stable medications for at least 30 days
Hoehn and Yahr stage I-IV
A study partner who can answer questions pertaining to daily functioning Additional Inclusion criteria for MSA patients, subjects must:
Have an existing diagnosis of MSA, using consensus criteria
Stable medications for at least 30 days
MSAp or MSAc
A study partner who can answer questions pertaining to daily functioning Additional Inclusion criteria for DLB patients, subjects must:
Have an existing diagnosis of probable DLB, using consensus criteria
Stable medications for at least 30 days
Clinical Dementia Rating Scale (CDR) \< 0.5
A study partner who can answer questions pertaining to daily functioning

Exclusion Criteria

General Exclusion Criteria (All Subjects)
History of vascular risk factors (e.g. hypertension, hyperlipidemia), if not well-controlled
Major psychiatric disease (e.g.schizophrenia)
History of stroke
Focal brain lesions on MRI scans
History of other major illnesses including, but not limited to, major kidney or liver problems or significant neurological illness
Recent surgery that is deemed major by our reviewing physician or nurse practitioner within the past 6 months
History of head trauma (as defined as having any insults to the brain that may have resulted from an external mechanical force, such as rapid acceleration or deceleration, impact, blast waves, or penetration by a projectile)
Impaired elimination (as defined as having problems with urination) unless being managed
Past or present diagnosis of bipolar disorder or other Axis I diagnosis, (treated depression is allowed)
Any present substance abuse including drug/alcohol abuse
Inability to lie flat on camera bed for up to 90 min
Pregnancy or breastfeeding
Metallic foreign bodies that would be affected by the MRI magnet, or fear of enclosed spaces likely to make the subject unable to undergo an MRI scan
Recent exposure to radiation (i.e., PET from other research) that, when combined with this study, would be above the allowable limits (50 milliSieverts) General MR and PET safety exclusion criteria listed below
Ferromagnetic implants such as aneurysm clips, surgical clips, prostheses, artificial hearts, valves with steel parts, metal fragments, shrapnel, metallic tattoos anywhere on the body, tattoos near the eye, steel implants, ferromagnetic objects such as jewelry or metal clips in clothing
Electrical implants such as cardiac pacemakers or perfusion pumps
Pre-existing medical conditions including a likelihood of developing seizures or claustrophobic reactions, and any greater than normal potential for cardiac arrest
Is unable to lie comfortably on a bed inside a PET camera with their head in the field of view for 60 to 90 minutes as assessed by physical examination and medical history (e.g. back pain, arthritis)
Pregnancy: A negative serum pregnancy test is required on the day of the PET procedure in women of child bearing potential
Body weight of \> 300 lbs (weight limit of the MRI table)
Breast feeding mothers Exclusion Criteria for Subjects Undergoing Blood Draws Through an Arterial Line During PET Scan
An abnormal result on the modified Allen's test on both hands
Raynaud syndrome
Bleeding disorder
Use of anticoagulants such as Coumadin, Plavix or Lovenox
An allergy to Lidocaine

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Charlestown?

Yes, this clinical trial (NCT06098612) has an active research site in Charlestown, MA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Parkinson's Disease Treatment Options in Charlestown, MA

If you're searching for parkinson's disease treatment options in Charlestown, MA, this clinical trial (NCT06098612) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Charlestown research site is actively enrolling participants for this early phase 1 clinical trial. You'll receive care from experienced parkinson's disease specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all parkinson's disease clinical trials near you to find additional studies recruiting in your area.

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