Houston, TXNCT07136779Now EnrollingIRB Ready

Participants With Advanced Solid Tumor Malignancies Clinical Trial in Houston, TX

Access cutting-edge participants with advanced solid tumor malignancies treatment through this clinical trial at a research site in Houston. Study-provided care at no cost to qualified participants.

Sponsored by VelaVigo Bio Inc

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Expert Care in Houston

Access participants with advanced solid tumor malignancies specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related participants with advanced solid tumor malignancies treatment provided free

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Check if you qualify for this participants with advanced solid tumor malignancies clinical trial in Houston, TX

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Why Participate?

  • No-Cost Study Care

  • Local to Houston

    Convenient for TX residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Houston site if eligible
  4. 4Begin participation

About This Participants With Advanced Solid Tumor Malignancies Study in Houston

This is a multicenter, open-label, multiple-dose, FIH Phase 1/2a trial. The Phase 1 portion adopts an accelerated titration for the first dose level, followed by BOIN design to identify the MTD and/or RP2D with potential backfill cohorts. The Phase 2a portion consists of dose optimization followed by cohort expansion to confirm safety and tolerability and to further evaluate the efficacy of the selected RP2D in selected solid tumor malignancies for VBC101.

Sponsor: VelaVigo Bio Inc

Who Can Participate

Inclusion Criteria

A participant must meet all of the following inclusion criteria to be eligible to participate in this trial:
1\. The participant or the participant's legally acceptable representative is willing and able to provide a written ICF before initiating any trial procedure.
2\. Histologically or cytologically confirmed unresectable advanced/metastatic solid tumor that has relapsed or progressed on or after standard systemic treatments, or is intolerable with standard treatment, or for which no standard treatment is available
3\. At least one measurable lesion as assessed by the investigator according to RECIST v1.1criteria
4\. Male or female adults (defined as ≥ 18 years of age)
5\. ECOG performance status 0-1
6\. Has LVEF ≥ 50% by either ECHO or MUGA within 28 days before enrollment.
7\. Life expectancy greater than 12 weeks
8\. Archived tumor tissue sample available or able to undergo a fresh biopsy collection.
9\. Adequate organ and bone marrow function
10\. Participants must meet the minimum washout period requirements before the first dose of investigational drug

Exclusion Criteria

1\. Any unresolved toxicity of Grade ≥2 from previous anti-cancer treatment, except for alopecia, neuropathy, or skin pigmentation changes. Participants with chronic but stable Grade 2 toxicities may be allowed to enroll after agreement between the study investigator and the Sponsor's Medical Monitor.
2\. Known or suspected brain metastases, or spinal cord compression, unless the condition has been treated, asymptomatic, and has been stable without requiring escalating doses of corticosteroids (equivalent to ≤10 mg/day prednisone) or anti-convulsant medications for at least four weeks prior for the first dose of investigational drug.
3\. Prior treatment with an ADC targeting EGFR and/or cMet (including VBC101)
4\. Prior treatment with any ADC carrying a TOP1i payload (including prior VBC101).
5\. Has a medical history of interstitial lung diseases (e.g., non-infectious interstitial pneumonia, pneumonitis, pulmonary fibrosis, and severe radiation pneumonitis) or current interstitial lung diseases or who are suspected to have these diseases by imaging at screening.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Houston?

Yes, this clinical trial (NCT07136779) has an active research site in Houston, TX that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Participants With Advanced Solid Tumor Malignancies Treatment Options in Houston, TX

If you're searching for participants with advanced solid tumor malignancies treatment options in Houston, TX, this clinical trial (NCT07136779) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Houston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced participants with advanced solid tumor malignancies specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all participants with advanced solid tumor malignancies clinical trials near you to find additional studies recruiting in your area.

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