Pittsburgh, PANCT07550127Now EnrollingIRB Ready

Peri-implantitis Clinical Trial in Pittsburgh, PA

Access cutting-edge peri-implantitis treatment through this clinical trial at a research site in Pittsburgh. Study-provided care at no cost to qualified participants.

Sponsored by University of Pittsburgh

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Expert Care in Pittsburgh

Access peri-implantitis specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related peri-implantitis treatment provided free

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Check if you qualify for this peri-implantitis clinical trial in Pittsburgh, PA

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Pittsburgh

    Convenient for PA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Pittsburgh site if eligible
  4. 4Begin participation

About This Peri-implantitis Study in Pittsburgh

The goal of this clinical trial is to learn how two standard surgical treatments for peri-implantitis affect inflammation around dental implants. Participants will be randomly assigned to receive resective surgery with implantoplasty or resective surgery with mechanical debridement only. Participants will provide blood samples before surgery, about 48 hours and 2 weeks after surgery. Participants will also provide a small gum tissue sample and fluid from around the implant at baseline and about 3 months after surgery. Participants will be followed in a maintenance program for up to 5 years.

Sponsor: University of Pittsburgh

Who Can Participate

Inclusion Criteria

To be enrolled the participant must met the following inclusion criteria:
Aged 18 or older.
In good general health, classified as ASA Physical Status I or II.
Diagnosed with peri-implantitis requiring resective surgical treatment, characterized by: Bleeding on probing (BOP) around dental implants. Probing pocket depths (PPD) greater than 6 mm. Implants in function for over 1 year with progressive bone loss exceeding 3 mm. Initial screening confirmed by panoramic radiographs, cone-beam computed tomography (CBCT), and clinical diagnosis. To be enrolled in the maintenance phase, participants must meet clinical stability criteria at the time of enrollment:
Probing depth (PD) ≤ 5 mm
Bleeding on probing (BOP) ≤ 1 point
Absence of suppuration (SOP)
Absence of progressive bone loss compared to pre-treatment bone levels

Exclusion Criteria

Patients with autoimmune or systemic inflammatory diseases (e.g., lupus, rheumatoid arthritis) that could alter immune cell profiles independent of local peri-implant inflammation.
Chronic use of systemic corticosteroids or immunosuppressants within the past 3 months.
Uncontrolled diabetes (HbA1c \> 7.5%) due to its potential impact on healing and immune response.
Active infection or antibiotic use in the 30 days prior to baseline sampling.
Pregnancy or breastfeeding.
Inability to undergo venipuncture or tolerate soft tissue biopsy.
Inability to attend the 3-month follow-up visit or comply with study protocol.
History of malignancy requiring systemic therapy within the past 5 years.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Pittsburgh?

Yes, this clinical trial (NCT07550127) has an active research site in Pittsburgh, PA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Peri-implantitis Treatment Options in Pittsburgh, PA

If you're searching for peri-implantitis treatment options in Pittsburgh, PA, this clinical trial (NCT07550127) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Pittsburgh research site is actively enrolling participants for this clinical trial. You'll receive care from experienced peri-implantitis specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all peri-implantitis clinical trials near you to find additional studies recruiting in your area.

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