NCT07439614 · State University of New York at Buffalo
Comparison of Root Canal Desinfection Protocols
What this study is about
Evaluate and compare the disinfecting effectiveness of two supplementary antimicrobial protocols in teeth with apical periodontitis
View original scientific description
Evaluate and compare the disinfecting efficacy of two supplementary antimicrobial protocols in teeth with apical periodontitis
Interventions
DEVICE
Desinfection device
Desinfection protocol with (LAI): Er,Cr:YSGG laser (2780 nm) delivered with a radial-firing tip.
DEVICE
Analytical microbiological methods
Endocator: Measures ATP levels (Endoscore and RLU) to rapidly assess bacterial load in less than one minute.
Primary outcome measures
Reduction of bacteria in the root canal system
Time frame: Immediately after the irrigation activation procedure, ATP levels will be measured, and qPCR analysis will be performed at the end of the study, once all samples have been collected.
Evaluation of the effectiveness of different irrigation activation devices by assessing bacterial reduction in the root canal system. ATP levels will be measured (Endoscore and RLU values) to provide a rapid assessment of bacterial load in less than one minute. Subsequently, bacterial reduction will be confirmed by quantitative polymerase chain reaction (qPCR) analysis
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Adult patients able to give informed consent and willing/able to comply with study procedures and follow-up.
- Molar teeth indicated for endodontic treatment.
- Teeth with intact pulp-chamber walls (no extensive coronal destruction).
- Necrotic pulp confirmed by pulp testing.
- Clinical and radiographic evidence of asymptomatic apical periodontitis.
Exclusion criteria
- Immature teeth
- Teeth with calcified or obliterated canals
- Teeth with extensive coronal destruction
- Teeth with previous endodontic treatment
- Symptomatic apical periodontitis
- Teeth with periodontal pockets greater than 4 mm
- Patients who have received systemic antibiotics in the last 3 months
- Patients with a history of diabetes or immune impairment
- Pregnant patients
Where
- Buffalo, New York
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jun 23, 2026 · Source of record for eligibility and locations