NCT07886268 · Tarsus Pharmaceuticals, Inc.
A Study to Evaluate the Efficacy and Safety of TP-06 for PCED
(Capellion)
What this study is about
Capellion is a Phase 2 trial comparing TP-06 2.0% with Vehicle in up to 32 adults with persistent corneal epithelial defects. Participants will receive treatment for 8 weeks and be followed for 2 additional weeks to assess corneal healing and safety.
View original scientific description
Capellion is a Phase 2 trial comparing TP-06 2.0% with Vehicle in up to 32 adults with persistent corneal epithelial defects. Participants will receive treatment for 8 weeks and be followed for 2 additional weeks to assess corneal healing and safety.
Interventions
DRUG
TP-06
TP-06 ophthalmic solution
DRUG
Vehicle of TP-06
Vehicle of TP-06 ophthalmic solution
Primary outcome measures
Proportion of participants achieving complete resolution of corneal fluorescein staining (CFS) in the study eye at day 56, maintained through day 70.
Time frame: Day 56 and Day 70
A participant will be considered to have achieved complete resolution of CFS when there is no residual fluorescein staining at the time of assessment and at the follow-up assessment.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Able and willing to provide written informed consent
- Presence of a non-infected persistent corneal epithelial defect (PCED) in one eye that has failed to heal after at least 10 days of appropriate standard-of-care treatment
- Stable lesion size between Screening and Baseline as assessed by the Investigator
Exclusion criteria
- Active ocular infection in either eye
- Corneal perforation or high risk of corneal perforation
- Severe eyelid abnormalities
- Ocular or eyelid surgery in the study eye within 3 months prior to Baseline (unless PCED was caused by surgery)
- Use of prohibited ophthalmic medications or procedures as defined in the protocol
- Any condition that, in the Investigator's judgment, would interfere with study participation or interpretation of results Note: Additional exclusion criteria apply, as defined in the protocol
Where
- Scottsdale, Arizona
- Tampa, Florida
- Atlanta, Georgia
- Alexandria, Minnesota
- Dover, New Jersey
- Palisades Park, New Jersey
- Babylon, New York
- Mt. Pleasant, South Carolina
- Houston, Texas
- Sugar Land, Texas
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Oct 21, 2026 · Source of record for eligibility and locations