NCT07694440 · Maze Therapeutics
A Phase 2 Study of MZE782 in Adults With PKU
(CIPheR)
What this study is about
The purpose of this study is to evaluate the safety, tolerability, and effectiveness of MZE782 in adults with Phenylketonuria (PKU).
View original scientific description
The purpose of this study is to evaluate the safety, tolerability, and efficacy of MZE782 in adults with Phenylketonuria (PKU).
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Males and females 18 to 75 years old
- Clinical diagnosis of PKU
- Willing and able to keep diet and protein intake consistent during the study
- For some study groups, is willing and able to stop certain PKU medications before starting study treatment
- For some study groups, may need to meet additional blood phenylalanine level or background-treatment requirements
- Meets minimum blood phenylalanine level requirements for study group Key
Exclusion criteria
- Is pregnant, breastfeeding, or planning to become pregnant or conceive a child during the study or within 90 days after the last dose
- Medical conditions or abnormal test results that could make participation unsafe or make it difficult to complete study procedures or interpret study results
- Has recently received another investigational drug
- Is unable to swallow tablets or tolerate oral medication Other inclusion/exclusion criteria defined in protocol apply.
Where
- Gordonville, Pennsylvania
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jul 10, 2026 · Source of record for eligibility and locations