Portland, ORNCT07477691Now EnrollingIRB Ready

Phenylketonuria Clinical Trial in Portland, OR

Access cutting-edge phenylketonuria treatment through this clinical trial at a research site in Portland. Study-provided care at no cost to qualified participants.

Sponsored by BioMarin Pharmaceutical

Quick Self-Assessment

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Expert Care in Portland

Access phenylketonuria specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related phenylketonuria treatment provided free

Apply for This Portland Location

Check if you qualify for this phenylketonuria clinical trial in Portland, OR

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Portland

    Convenient for OR residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Portland site if eligible
  4. 4Begin participation

About This Phenylketonuria Study in Portland

Study 165-401 is a Phase 4, open-label study designed to examine the concomitant use of methotrexate (MTX) to suppress immune responses to Palynziq and improve tolerability and efficacy in adults with PKU.

Sponsor: BioMarin Pharmaceutical

Who Can Participate

Inclusion Criteria

Adults between 18 and 65 years old
Have a confirmed diagnosis of phenylketonuria (PKU)
Are in generally good health based on medical evaluation
Are willing and medically eligible to receive Palynziq and methotrexate (MTX) Cohort A: Have never taken Palynziq before and are willing to start it during the study Cohort B: Have blood \> 600 μmol/L after taking Palynziq for at least 24 weeks, are on a daily dose of at least 20mg and unable to increase the dose further
Agree to use required contraception if they or their partner could become pregnant
Are willing to carry two epinephrine devices at all times during Palynziq treatment

Exclusion Criteria

Pregnant, breastfeeding, planning to become pregnant, planning to father a child, or not using effective birth control if applicable
Have a known severe allergy or hypersensitivity reaction to methotrexate (MTX), Palynziq, or other PEG-containing medications
Have a serious active infection or a history of severe or recurrent infections
Have significant medical conditions that may affect safety or participation (such as serious heart, lung, liver, kidney, immune, neurological, psychiatric, or cancer-related conditions)
Have a history of substance or alcohol abuse within the past 12 months
Have had an organ transplant or are taking chronic immunosuppressive medications
Are currently taking medications that are not allowed in the study, including other PKU treatments besides Palynziq
Are using, or plan to use, injectable PEG-containing medications other than Palynziq during the study
Have major surgery planned during the study participation period
Are currently participating in another clinical study involving Palynziq
In the opinion of the study doctor, are not a suitable candidate for the study or may have difficulty complying with study requirements

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Portland?

Yes, this clinical trial (NCT07477691) has an active research site in Portland, OR that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Phenylketonuria Treatment Options in Portland, OR

If you're searching for phenylketonuria treatment options in Portland, OR, this clinical trial (NCT07477691) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Portland research site is actively enrolling participants for this clinical trial. You'll receive care from experienced phenylketonuria specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all phenylketonuria clinical trials near you to find additional studies recruiting in your area.

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Secure · Expert Care · Portland, OR