Measuring Outcomes With Validated Exercise

Inclusion criteria

• Participant is willing and able to comply with study instructions, study visits, and procedures including wearing a tight-fitting respiratory mask
• Able to ambulate independently, including walking/running on a treadmill without assistance.
• Demonstrates fluency in English
• Montreal Cognitive Assessment (MoCA) score of ≥26
• Score of 100 on the Barthel Index
• Participant has reliable access to internet

Exclusion criteria

• Participation in other digital device trials within 1 week or investigational drug trials within 5 half-lives of last dose.
• Allergy to polyurethane resin (strap/wristband component), silicone rubber, nickel and/or steel.
• Has any planned surgical, dental, or medical procedure that would overlap with study participation.
• Participants with cardiac pacemakers, electronic pumps or any other implanted medical devices.
• Has any clinically significant medical disorder, condition, disease or clinically significant finding at intake that precludes participant's participation in study activities including any self-reported diagnosis of cardiovascular disease, metabolic disorder, chronic obstructive pulmonary disease, cerebral vascular accident/stroke, stage 2 hypertension, use of any medication which alters heart rate (HR) response (e.g., Beta blockers and calcium blockers), any history of myocardial infarction high-risk unstable angina, uncontrolled cardiac arrhythmias, active endocarditis, symptomatic severe aortic stenosis, decompensated symptomatic heart failure, acute pulmonary embolus or pulmonary infarction, acute noncardiac disorder that my affect exercise performance/be worsened by exercise (e.g., infection, renal failure), acute myocarditis or pericarditis, left main coronary stenosis or its equivalent, moderate stenotic valvular heart disease, electrolyte abnormalities, tachyarrhythmia or bradyarrhythmia's, atrial fibrillation, high-degree Atrioventricular (AV) block, mobility/orthopedic limitations.
• Has any skin conditions, open wounds, or other conditions on the wrists that may interfere with wrist-worn wearable sensors.
• Has tuberculosis, oral lesions (sores, bleeding gums), any respiratory illnesses, and/or any other known transmissible infectious diseases during subsequent study visits.
• Any changes to recorded health status from intake that would deem participant to be ineligible during subsequent study visits.
• Has claustrophobia
• Participants who are investigational site staff members directly involved in the conduct of the study and their family members, site staff members otherwise supervised by the investigator, or participants who are employees directly involved in the conduct of the study.
• Has a history of regular alcohol consumption exceeding 7 drinks/week for females or 14 drinks/week for males (1 drink = 5 ounces (150 mL) wine, 12 ounces (360 mL) of beer, or 1.5 ounces (45 mL) of hard liquor) within 12 months of Visit 1 as disclosed by participant during evaluation.
• Is a female who is breastfeeding or pregnant, as disclosed by the participant.
• Class III Obesity: Body Mass Index (BMI) ≥ 40 kg/m2
• Underweight: BMI \< 18.5 kg/m2
• Resting systolic blood pressure ≥ 160 mmHg and/or diastolic blood pressure ≥ 100 mmHg
• Resting heart rate \<40 or ≥ 110 beats/min (for participants ≥60 years)
• Current tobacco/nicotine use