NCT03797495 · Indiana Hemophilia &Thrombosis Center, Inc.
Study of Individuals Affected With Hypoplasminogenemia
(HISTORY)
What this study is about
This is an Investigator initiated reviewing past data and forward-looking single group of participants study.
View original scientific description
This is an Investigator initiated retrospective and prospective single cohort study.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Signed informed consent and assent as applicable (Appendix 1)
- A. Males or females with type 1 PD diagnosed locally with plasminogen activity levels \<50% OR B. First degree family members of a person diagnosed with type 1 PD (includes parents, siblings, half-siblings)
- All ages included
- Available clinical history and treatment for at least 1 year prior to entry except for infants \< 1 year of age
- Willingness to provide samples for analysis including DNA, plasma etc.
- Willingness to participate in prospective follow-up for up to 3 years
Exclusion criteria
- Previous organ transplant recipient
- Any psychiatric disorder, other mental disorder, or any other medical disorder that impairs the subject's ability to give informed consent or to comply with the requirements of the study protocol
- Refuses to provide informed consent
- Special patient populations, including prisoners or, are deemed medically or cognitively unsuitable for research by their treating physician
- Inability to obtain a blood sample due to poor or limited venous access
Where
- Birmingham, Alabama
- Chicago, Illinois
- Indianapolis, Indiana
- Minneapolis, Minnesota
- East Setauket, New York
- Syracuse, New York
- Raleigh, North Carolina
- Winston-Salem, North Carolina
- Pittsburgh, Pennsylvania
- Nashville, Tennessee
- Forth Worth, Texas
- Houston, Texas
And 1 more location — see the full list below.
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jun 4, 2026 · Source of record for eligibility and locations