Boston, MANCT06713382Now EnrollingIRB Ready

Pleural Effusion Associated With Pulmonary Infection Clinical Trial in Boston, MA

Access cutting-edge pleural effusion associated with pulmonary infection treatment through this clinical trial at a research site in Boston. Study-provided care at no cost to qualified participants.

Sponsored by Beth Israel Deaconess Medical Center

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IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related pleural effusion associated with pulmonary infection treatment provided free

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Why Participate?

  • No-Cost Study Care

  • Local to Boston

    Convenient for MA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Boston site if eligible
  4. 4Begin participation

About This Pleural Effusion Associated With Pulmonary Infection Study in Boston

The purpose of this protocol is to conduct a pilot prospective non-blind clinical trial to evaluate the efficacy and safety of a novel saline irrigation technique as an adjunct to standard interventions for treating retained pleural infections. Intrapleural fibrinolytic therapy (IPFT) is commonly used for infections not adequately managed with antibiotics and intercostal tube drainage, while saline irrigation serves as an alternative for cases with a high bleeding risk where IPFT is not feasible. The efficacy of saline irrigation combined with IPFT remains unexplored. The hypothesis is that saline irrigation could be an effective and safe addition to IPFT for patients with persistent pleural infections. The specific aims of the study include: Determine the efficacy of saline irrigation as add-on therapy to IPFT: Compare the clinical outcomes of patients receiving saline irrigation combined with IPFT to those receiving IPFT alone to determine if the addition of saline irrigation offers significant benefits. Outcomes include changes in inflammatory markers, imaging characteristics (echography and CT), volume of pleural fluid drained, chest tube duration, hospital length of stay, and the need for subsequent surgical intervention. Assess the safety and tolerability of saline irrigation plus IPFT: Compare complications and patient comfort in those receiving saline irrigation combined with IPFT to those receiving IPFT alone.

Sponsor: Beth Israel Deaconess Medical Center

Who Can Participate

Inclusion Criteria

Age ≥18 years.
Presence of purulent pleural fluid or pleural fluid analysis with any of the following:
Glucose \< 40 mg/dL.
LDH \> 1000 IU/L.
Presence of bacterial or fungal organisms on Gram stain or culture.
Chest tube placement with less than 200 mL drainage in 24 hours.
Indication for IPFT treatment based on treating physician's criteria.
Radiographic evidence of septations on chest ultrasound (US) or loculations on low-dose chest computed tomography (CT).

Exclusion Criteria

Inability to provide informed consent.
Pregnant patients.
Patients with significant comorbidities that may interfere with the study -outcomes (e.g., terminal malignancy).
Complicated sympathetic effusion.
Hepatic hydrothorax.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Boston?

Yes, this clinical trial (NCT06713382) has an active research site in Boston, MA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Pleural Effusion Associated With Pulmonary Infection Treatment Options in Boston, MA

If you're searching for pleural effusion associated with pulmonary infection treatment options in Boston, MA, this clinical trial (NCT06713382) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Boston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced pleural effusion associated with pulmonary infection specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all pleural effusion associated with pulmonary infection clinical trials near you to find additional studies recruiting in your area.

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