NCT05868330 · Melinda Seering
Comparison of Interscalene Catheter to Single Injection Interscalene Blocks for Total Shoulder Arthroplasties
What this study is about
Comparison of post-operative pain after total shoulder surgery. The Principle Investigator will be comparing Exparel single shot block to Interscalene catheter
View original scientific description
Comparison of post-operative pain after total shoulder surgery.
Interventions
PROCEDURE
Interscalene Catheter
Pre-operatively the patient will have a interscalene catheter placed by a regional skilled anesthesiologist. The initial block will be with 20 cc of 0.5% Bupivacaine and maintained on an infusion post-operatively at 8cc/hr of 0.2% ropivacaine as is our intuitions protocol
PROCEDURE
Exparel Single Shot Interscalene Block
Pre-operatively the patient will have a interscalene single shot block with 133 mg Liposomal Bupivacaine and 10 ccs 0.5% Bupivacaine placed by a regional skilled anesthesiologist.
Primary outcome measures
Pain Score Assessed by functional pain score at POD 1
Time frame: The primary outcome will occur at 1 day after surgery date
The primary outcome to be assessed is to determine if there is a quantitative difference in post-operative pain scores as a result of the administration of a interscalene Exparel block versus the administration of an interscalene catheter for shoulder replacement surgery. The functional pain scale is a slightly more quantifiable measure of pain used in a diverse adult population to look at functional ability with pain. The Functional Pain Scale incorporates a "0" to "5" scale, with worsening pain being registered by higher numbers.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Patients who have or are:
- Orthopedics service patients having reverse shoulder replacement surgery
- ASA class I, II, or III.
- Patients at least 18 years old but less than 90 years old.
- Patients giving informed consent.
- Non-Emergency Surgery
Exclusion criteria
- Patients who have or are:
- An inability to cooperate during the block placement.
- Patients who do not meet criteria for a regional block: such as those on anti-coagulation,
- Significant pulmonary disease or allergy to medications used for peripheral nerve blocks (Exparel, Bupivacaine and Ropivacaine)
- Neuropathy of the planned extremity to block
- Documented Kidney Failure
- Documented Liver Failure
- A lack of or inability to give informed consent.
- Currently incarcerated.
- Unable to communicate in English
- Chronic pre-operative opioid use (greater than 20 MME opioid used)
- Revision surgery
Where
- Iowa City, Iowa
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Frequently asked questions
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Will I receive a placebo instead of treatment?
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Data: ClinicalTrials.gov · synced Nov 10, 2025 · Source of record for eligibility and locations