Is NCT05149534 recruiting in Temple, TX?

Yes, NCT05149534 is currently recruiting participants at its Temple, TX location. This post traumatic stress disorder clinical trial is actively enrolling qualified participants.

How do I join the post traumatic stress disorder clinical trial in Temple?

To join this clinical trial in Temple, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Temple clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Post Traumatic Stress Disorder Clinical Trial in Temple, TX

About This Post Traumatic Stress Disorder Study in Temple

Post-traumatic stress disorder (PTSD) is prevalent and represents a high healthcare burden among Veterans. Repetitive transcranial magnetic stimulation (rTMS) is a brain-based therapy that may be effective for treating PTSD. The theorized mechanism of rTMS is enhancement of emotional flexibility via the dorsolateral prefrontal cortex node of the brain's cognitive control network. Given this mechanism of action, adding rTMS to an evidence-based psychotherapy (EBP) for PTSD may enhance treatment effects. Written exposure therapy (WET) is a brief EBP for PTSD found to reduce attrition compared to lengthier first line treatments. In this study, the investigators will determine if active rTMS added to WET compared with sham rTMS added to WET results in improved PTSD outcomes. The investigators will also determine if emotional flexibility is a mechanism of symptom improvement. This work will improve upon PTSD intervention and inform the mechanism of treatment effectiveness for Veterans suffering from PTSD.

Sponsor: VA Office of Research and Development

Who Can Participate

Inclusion Criteria

-All veterans are eligible to be included in the study if they meet all the following criteria:

English-speaking and able to provide written informed consent;

diagnosed with PTSD;

between the ages of 18 and 60 years. Participants over age 60 will not be included, as aging is known to impact brain structure, and thus the potential accuracy of the rTMS target, independently of PTSD.

Exclusion Criteria

Individuals with history of seizures or other serious neurological history including acquired, developmental or degenerative neurologic illness, identified through medical chart review, will be excluded due to potential lowered threshold for seizures during rTMS stimulation.

The effects of rTMS are unknown on fetal development, therefore, women who are pregnant will be excluded.

Participants will also be screened and excluded if any of the following are met:

current psychosis including psychotic disorder,

bipolar disorder,

schizophrenia; or another severe cognitive or psychiatric disorder;

positive screen for current suicidal intent and plan \[with a score of 2 or 3 on BDI-2 item 9\];

current substance use disorder; or substance use in the last 12 hours before the rTMS session.

The investigators note that PTSD is often comorbid with traumatic brain injury (TBI) in military veterans who were deployed to a war zone. The investigators will use the Department of Defense and Veterans Affairs consensus-based classification of TBI severity for classification of TBI.

Participants with moderate or severe TBI will be excluded.

Participants with mild traumatic brain injury (mTBI) or concussion will be enrolled. This will enhance the ecological validity of the study.

Participants with cognitive impairment as evidenced by a Montreal Cognitive Screen (MoCA) less than 23/30 or estimated baseline intellectual ability of a standard score of less than 80 on a word reading test will be excluded due to potential neurocognitive differences.

Participants on psychotropic medications will not be excluded, but participants will be required to be stable on their medication for at least four weeks prior to beginning the study and throughout the time of study.

Participants enrolled in long term, supportive psychotherapy (i.e. not an evidence-based psychotherapy (EBP)) may continue to be involved in their treatment throughout the study. However, participants involved in a concurrent EBPs will be excluded. Participants will be asked to disclose whether they chose to participate in an EBP during the course of the treatment or followup phases of the study.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Temple?

Yes, this clinical trial (NCT05149534) has an active research site in Temple, TX that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Post Traumatic Stress Disorder Treatment Options in Temple, TX

If you're searching for post traumatic stress disorder treatment options in Temple, TX, this clinical trial (NCT05149534) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Temple research site is actively enrolling participants for this clinical trial. You'll receive care from experienced post traumatic stress disorder specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all post traumatic stress disorder clinical trials near you to find additional studies recruiting in your area.

Post Traumatic Stress Disorder Clinical Trial in Temple, TX

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