NCT06986161 · Clinical Nutrition Research Center, Illinois Institute of Technology
Optimizing Mango's Glycemic Impact: Investigating Mango Consumption Timing in Prediabetic Individuals
(MG3)
What this study is about
The purpose of this study is to investigate the effect of mango intake on metabolic and inflammatory responses relative to meals in individuals at risk of developing diabetes, as well as to understand how the beneficial compounds found in mangoes are absorbed and processed in the body.
View original scientific description
The purpose of this study is to investigate the effect of mango intake on metabolic and inflammatory responses relative to meals in individuals at risk of developing diabetes, as well as to understand how the beneficial compounds found in mangoes are absorbed and processed in the body.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Be between 20-60 years old.
- Have a BMI of 25-35 kilograms per square meter.
- Have fasting blood glucose between 100-125 milligrams per deciliter or Glycated hemoglobin (HbA1c) between 5.7-6.4%.
- Be non-smokers for at least 12 months.
- Be generally healthy, with no major organ-related diseases.
- Not take medications or supplements that could interfere with the study.
- Be able to follow study procedures, including dietary restrictions and scheduled visits.
Exclusion criteria
- Smoke, vape, or use marijuana.
- Have allergies or intolerance to mangoes or study foods.
- Have blood pressure above 160/100 millimeters of Mercury.
- Have fasting blood glucose above 125 milligrams per deciliter.
- Have a history of major heart disease, stroke, or cancer in the past five years.
- Be pregnant, planning to become pregnant, or breastfeeding.
- Take anti-inflammatory drugs or certain dietary supplements.
- Have had major surgery or trauma in the past two months.
- Follow extreme diets (e.g., vegan, Atkins).
- Have used antibiotics in the last six weeks.
- Have a history of eating disorders or substance abuse in the past two years.
- Drink more than three cups of coffee or tea per day.
- Have donated blood in the last three months.
- Be professional athletes or do excessive exercise.
- Have had weight changes of more than 11 pounds in the past two months.
- Work overnight shifts.
Where
- Chicago, Illinois
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jul 11, 2025 · Source of record for eligibility and locations