NCT07624500 · Clinical Nutrition Research Center, Illinois Institute of Technology
Food and Metabolism Study
(FAM)
What this study is about
In this study, Investigators are interested in looking at the influence of eating avocados regularly, which are rich in healthy fats, fibers, and unique carbohydrates, on triglyceride and glucose metabolism in people with prediabetes and insulin resistance.
View original scientific description
In this study, Investigators are interested in looking at the influence of eating avocados regularly, which are rich in healthy fats, fibers, and unique carbohydrates, on triglyceride and glucose metabolism in people with prediabetes and insulin resistance.
Interventions
OTHER
Avocado meal plan
American Diet with avocado
OTHER
Control meal plan
American diet
Primary outcome measures
Changes in serum biomarker: triglycerides
Time frame: baseline and 4 weeks
analyzed by McLendon labs
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Men or women, 40-70 years of age.
- Fasting triglycerides (TG) \>115 mg/dL.
- Insulin resistance as measured by Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) \>2.5.
- Able to provide informed consent.
- Able to comply with and perform the procedures requested by the protocol, specifically eat all the meals and snacks provided by the study which will be almost all your food (\~ 80% of calories per day).
- Able to come to the clinic up to 6 times during the study.
- Able to maintain usual physical activity pattern.
- Able to avoid/abstain from alcohol and vigorous physical activity for 24 hours prior to and during study visit.
Exclusion criteria
- Men and women with known or suspected intolerance, allergies or hypersensitivity to study foods or interventions.
- Fasting blood sugar ≥125 mg/dL. Men and women with blood pressure \>160 mmHg (systolic) / 100 mmHg (diastolic) at the screening visit.
- Men and women with history of diabetes cardiovascular events, respiratory, renal, gastrointestinal, hepatic or eye disease or surgery- within a year.
- Men and women who have or had cancer other than non-melanoma skin cancer in the past 5 years.
- Men and women taking over the counter or prescription medications or dietary supplements that may interfere with study procedures or endpoints.
- Men and women who are on a specialized diet (vegan, vegetarian, keto, etc.). - - Men and women who consume nuts or peanuts daily or most days of the week.
- Men and women who are not weight stable (+/-10lbs in previous 2 months). Men and women who have excessive use of drugs or alcohol (ie., addictions) within the past 2 years.
- Men and women with documented physical or mental disease/condition, which might limit participation in or completion of the study or, that, in the opinion of the investigator, could interfere with the interpretation of the study results.
- Women who are known to be pregnant or who are intending to become pregnant over the course of the study.
- Women who are lactating.
- Major trauma or a surgical event within 2 months (or longer depending on trauma or event) and after consultation with PI. Has used antibiotics within the previous 2 months.
- History of an eating disorder (e.g., anorexia nervosa, bulimia nervosa, or binge eating) diagnosed by a health professional.
- Excessive coffee and tea consumers (\> 4 cups/d).
- Donated blood within the last 3 months.
- Women who are taking an unstable dose and brand of hormonal contraceptives and/or a stable dose and brand for less than 6 months.
- Unusual working hours (working overnight).
Where
- Chicago, Illinois
Collaborators
Hass Avocado Board
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jul 1, 2026 · Source of record for eligibility and locations