Is NCT05745441 recruiting in Bethesda, MD?

Yes, NCT05745441 is currently recruiting participants at its Bethesda, MD location. This prediabetes clinical trial is actively enrolling qualified participants.

How do I join the prediabetes clinical trial in Bethesda?

To join this clinical trial in Bethesda, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Bethesda clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

PreDiabetes Clinical Trial in Bethesda, MD

About This PreDiabetes Study in Bethesda

Obesity and its metabolic complications are leading causes of global morbidity and mortality. Evidence is mounting that inappropriate timing of food intake contributes to obesity. Specifically, late eating is associated with greater weight gain and metabolic syndrome. However, the mechanism by which late eating harms metabolism is not fully understood but may be related to mis-timing of food intake in relation to the body's endogenous circadian rhythm. Conversely, harmonization of eating timing with endogenous circadian rhythm may optimize metabolic health. In this study the investigators will use gold-standard methods of characterizing circadian rhythm in humans to examine the metabolic impacts food timing relative to endogenous circadian rhythm.

Sponsor: Johns Hopkins University

Who Can Participate

Inclusion Criteria

For the Normal-Weight Healthy (NWH) cohort: Healthy male and female adults, age 18-50, with BMI 18-24.9 kg/m2 inclusively

For the Obesity-Prediabetes (OPD) cohort: Male and female adults, age 18-50, with BMI ≥30 kg/m2 and prediabetes

All participants must be able to understand study procedures, to comply with the procedures for the entire length of the study and be fully mobile.

Exclusion Criteria

Sleep disorder including insomnia, untreated moderate-severe sleep apnea, restless leg syndrome, or narcolepsy

Night shift work

Extreme delayed sleep phase defined as self-reported routine bedtime later than 1:00 AM or having mid-sleep on free days later than 5:00 AM on the Munich Chronotype Questionnaire (MCTQ) or DLMO later than 24:00

Gastroesophageal reflux disease that affects ability to tolerate a dinner close to bedtime

Active smoking

Current drug or alcohol use or dependence that, in the opinion of the site investigator, would interfere with adherence to study requirements.

Diabetes (type 1 or 2) or on any diabetes medications besides metformin

Evidence of metabolic or cardiovascular disease, or disease that may influence metabolism (e.g. cancer, thyroid disease)

Hemoglobin A1c ≥5.7% for NWH cohort; Hemoglobin A1c ≥6.5% for OPD cohort

Hemoglobin \< 10 g/dL

Self-reported kidney disease

Any known history of an inherited metabolic disorder

Pregnant or lactating female (pregnancy test will be required prior to metabolic visits)

Peri-menopausal or post-menopausal female as determined by follicle stimulating hormone of \> 30 mIU/mL or fewer than 3 menstrual periods in 6 months

Professional or collegiate athlete

Participants who have travelled across time zones must have adequate time to recover from jet lag prior to enrollment (i.e., at least 3 days per time zone). Travel across \>1 time zone after enrollment in the study will not be permitted.

Weight less than 40 kg or more than 180 kg

Gastrointestinal disorders that can lead to obstruction of the digestive tract (i.e. diverticular disease, history of bowel obstruction, inflammatory bowel disease, motility disorder)

History of any surgical procedures in the gastrointestinal tract.

Swallowing disorders

Taking any prescription medication or other drug that may influence metabolism (e.g. diet/weight-loss medication, asthma medication, blood pressure medication, psychiatric medications, corticosteroids, or other medications at the discretion of the PI and/or study team)

Chronic use of sedative hypnotics, anxiolytics, opiates

Use of medications that can affect circadian rhythm (beta blockers, melatonin)

Presence of a cardiac pacemaker or other implanted electro-medical devices

Those who have to undergo strong electromagnetic field during the period of use of the ingestible thermosensor (i.e. MRI)

Weight loss or gain of ≥ 5% of total body weight over the preceding 3 months

Currently participating in a weight loss program

Prior bariatric surgery

Volunteers with strict dietary concerns (e.g. vegetarian or kosher diet, food allergies)

History of significant intravenous access issues

Non-English speaking individuals: The complexity of the instructions for various components of the study would make the study procedures difficult to follow in the setting of a language barrier.

Other conditions or situations at the discretion of the PI

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Bethesda?

Yes, this clinical trial (NCT05745441) has an active research site in Bethesda, MD that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

PreDiabetes Treatment Options in Bethesda, MD

If you're searching for prediabetes treatment options in Bethesda, MD, this clinical trial (NCT05745441) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Bethesda research site is actively enrolling participants for this clinical trial. You'll receive care from experienced prediabetes specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all prediabetes clinical trials near you to find additional studies recruiting in your area.

PreDiabetes Clinical Trial in Bethesda, MD

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