Rochester, MNNCT02026388Now EnrollingIRB Ready

Primary Hyperoxaluria Clinical Trial in Rochester, MN

Access cutting-edge primary hyperoxaluria treatment through this clinical trial at a research site in Rochester. Study-provided care at no cost to qualified participants.

Sponsored by Mayo Clinic

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Expert Care in Rochester

Access primary hyperoxaluria specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related primary hyperoxaluria treatment provided free

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Check if you qualify for this primary hyperoxaluria clinical trial in Rochester, MN

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Rochester

    Convenient for MN residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Rochester site if eligible
  4. 4Begin participation

About This Primary Hyperoxaluria Study in Rochester

This study is being done to obtain samples from patients with primary hyperoxaluria, cystinuria, adenine phosphoribosyl transferase (APRT) deficiency, and Dent disease, and from their family members, for use in future research.

Sponsor: Mayo Clinic

Who Can Participate

Inclusion Criteria

Diagnosis of primary hyperoxaluria (PH) meeting one or more of the following criteria:
Liver biopsy documenting alanine-glyoxylate aminotransferase (AGT) activity below the normal reference range confirming PH type 1 OR Liver biopsy documenting glyoxylate reductase/hydroxypyruvate reductase (GR/HPR) activity below the normal reference range confirming PH type 2
Molecular genetic analysis (DNA testing) confirming mutations known to cause PH type 1, PH type 2, or PH type 3
Urinary oxalate excretion of greater than 0.8 mmol/1.73 m2/day (\>70 mg/1.73 m2/day) in the absence of a identifiable causes of secondary hyperoxaluria, including gastrointestinal disease known to cause enteric hyperoxaluria
A patient in end stage kidney failure, in whom neither a liver biopsy nor mutational analysis are available must have: (a) A plasma oxalate concentration of greater than 60 umol/L and a kidney biopsy confirming extensive oxalate deposits OR (b) Evidence of systemic oxalosis
Participants in the previous protocol "Tissue Bank of Urine, Blood, and Tissue Samples Collected from the Patients with Primary Hyperoxaluria" 'Mayo IRB #' #80-04. They have already consented to bank their samples and that consent will serve to enroll them in this study.
Diagnosis of Dent disease meeting one or more of the following criteria:
Identified mutation of the gene that encodes for chloride exchange transporter 5 (CLCN5)
Low molecular weight proteinuria and hypercalciuria
Low molecular weight proteinuria and nephrocalcinosis
Diagnosis of APRT disease meeting one or more of the following criteria:
Suspected dihydroxyadeninuria and absent APRT enzyme activity measured in red blood cells (RBCs).
Homozygosity, or compound heterozygosity, for known disease-causing APRT mutations.
Passage of dihydroxyadenine stones (confirmed with stone analysis).
Diagnosis of Cystinuria meeting one or more of the following criteria:
Stone analysis demonstrating that the stone contains cystine
Increased urinary cystine excretion (\>250 mg/gm creatinine)
Relative of someone with confirmed primary hyperoxaluria, Dent disease, APRT deficiency (also known as dihydroxyadeninuria), or cystinuria

Exclusion Criteria

Stone formers who do not meet the inclusion criteria for primary hyperoxaluria, cystinuria, Dent disease, or APRT deficiency.
Unwilling or unable to provide consent/assent.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Rochester?

Yes, this clinical trial (NCT02026388) has an active research site in Rochester, MN that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Primary Hyperoxaluria Treatment Options in Rochester, MN

If you're searching for primary hyperoxaluria treatment options in Rochester, MN, this clinical trial (NCT02026388) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Rochester research site is actively enrolling participants for this clinical trial. You'll receive care from experienced primary hyperoxaluria specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all primary hyperoxaluria clinical trials near you to find additional studies recruiting in your area.

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