Leveraging Regulatory Flexibility for Methadone Take-Home Dosing to Improve Retention in Treatment for Opioid Use Disorder

BEHAVIORAL

Clinic-Level Multidimensional Intervention

The proximal goal of the intervention will be to increase OTP uptake of flexible THD. The intervention addresses facilitators and barriers to THD practices as identified by existing studies as well as those found during the first phase of the current project. The intervention will be designed to address the information gaps, training needs, and beliefs of individuals across the organizations.

Change from Baseline in 7-Day THD Prescriptions

Time frame: Pre-Intervention (from Baseline up to Month 30), Post-Intervention (from Month 6 up to Month 36)

7-day THD is defined as a prescription to pick up doses of methadone every 7 days or less often.

Change from Baseline in 14-Day THD Prescriptions

Time frame: Pre-Intervention (from Baseline up to Month 30), Post-Intervention (from Month 6 up to Month 36)

14-day THD is defined as a prescription to pick up doses of methadone every 14 days or less often.

Change from Baseline in 28-Day THD Prescriptions

Time frame: Pre-Intervention (from Baseline up to Month 30), Post-Intervention (from Month 6 up to Month 36)

28-day THD is defined as a prescription to pick up doses of methadone every 28 days or less often.

Change from Baseline in OTP Care Retention

Time frame: Pre-Intervention (from Baseline up to Month 30), Post-Intervention (from Month 6 up to Month 36)

Will be calculated only among patients who have been in treatment for less than 12 months at the start of the study.

Change from Baseline in Number of Emergency Department Visits

Time frame: Pre-Intervention (from Baseline up to Month 30), Post-Intervention (from Month 6 up to Month 36)

Change from Baseline in Number of Hospitalizations

Time frame: Pre-Intervention (from Baseline up to Month 30), Post-Intervention (from Month 6 up to Month 36)

Change from Baseline in All-Cause Mortality

Time frame: Pre-Intervention (from Baseline up to Month 30), Post-Intervention (from Month 6 up to Month 36)

All-Cause Mortality defined as death due to any cause.

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Will I receive a placebo instead of treatment?

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