Is NCT07325721 recruiting in Charleston, SC?

Yes, NCT07325721 is currently recruiting participants at its Charleston, SC location. This prostate cancer clinical trial is actively enrolling qualified participants.

How do I join the prostate cancer clinical trial in Charleston?

To join this clinical trial in Charleston, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Charleston clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Prostate Cancer Clinical Trial in Charleston, SC

About This Prostate Cancer Study in Charleston

This study is for adult men with previously untreated high risk, very high risk, or pelvic lymph node positive prostate cancer. The purpose of this study is to evaluate the safety and effectiveness of the combination of two emerging radiation treatment techniques (hypofractionated radiotherapy and microboost technique). Participation will include standard of care visits along with questionnaires and blood draws completed for research purposes. There is optional banking of blood and prostate biopsy tissue which will not require extra biopsies. Participation in this study is anticipated to last approximately 6 weeks with follow up every three months for two years then twice yearly for years 3-5.

Sponsor: Medical University of South Carolina

Who Can Participate

Inclusion Criteria

Provision of signed and dated informed consent form.

Stated willingness to comply with all study procedures and availability for the duration of the study.

Biologically male patients aged 18 years and older.

Ability to receive pelvic radiotherapy and be willing to adhere to the protocol regimen.

Previously untreated prostate cancer (with cytotoxic chemotherapy, cryotherapy, ablative treatment, surgical or radiation therapy). Prior transurethral resection of prostate (TURP) is permitted if 90 days or more prior to the start of radiotherapy.

Localized or locally advanced prostate cancer meeting NCCN criteria for high risk, very high risk or non-metastatic, pelvic lymph node positive defined as having at least one or more of the following:

PSA \>20 ng/mL prior to starting ADT.

cT3a-T4 by digital exam or imaging.

Gleason score of 8-10 (grade group 4 or 5).

Staged as N1M0 by the treating investigator (pelvic lymph node positive, below the aortic bifurcation) based on soft tissue imaging within 120 days prior to registration (may include CT, MRI or PSMA PET/CT, of fluciclovine choline PET/CT).

History and physical exam within 120 days prior to registration.

ECOG performance status 0-2.

Be able to undergo MRI of the prostate and/or pelvis as a component of RT planning.

Have at least one MRI visible target for microboost (PI-RADS≥ 4 version 2.0).

Bone and soft tissue imaging as clinically indicated for staging within 120 days prior to registration.

For males: use of condoms or other methods to ensure effective contraception with partner during radiation and for six months after completion of radiation.

Adequate hematologic function within 120 days prior to registration as defined by:

hemoglobin \>=9.0 g/dL independent of transfusion, and

platelet count \>= 100,000 x 10 \^9/microliter independent of transfusion.

Adequate hepatic function within 120 days prior to registration defined as total bilirubin \<2 x institutional upper limits of normal (ULN is 1.2 mg/dL). If labs are done at outside institution, total bilirubin should be \<2.4.

Agreeable and eligible to receive long term (defined as 12-36 months) ADT as a standard component of prostate cancer therapy.

Exclusion Criteria

1\. Concurrent use of testosterone supplementation unless discontinued by time of registration. 2\. Definitive radiologic evidence of metastatic disease outside of the pelvic nodes on conventional imaging (bone scan, CT scan, MRI). 3\. Prior pelvic radiotherapy. 4. Pre-existing conditions or overall health status which disqualifies the patient from curative intent-RT. Patients with life expectancy less than 5 years are not eligible. 5\. Treatment with another investigational prostate cancer therapy within 12 months. 6\. Prior total prostatectomy, cryotherapy, high-intensity focused ultrasound, irreversible electroporation, MRI ablation, laser ablation, transurethral ultrasound ablation, aquablation directed towards the prostate for any prostate disease or condition. 7\. Prior or concurrent invasive pelvic malignancy (except non-melanomatous skin cancer) or lymphomatous or hematogenous malignancy, unless disease free for a minimum of 5 years. 8\. Any condition that, in the opinion of the investigator, would preclude participation in this study. 9\. Prior pharmacologic androgen ablation for prostate cancer is allowed only if the onset of androgen ablation (both LHRH agonist and oral anti-androgen) is ≤ 90 days prior to registration. 10\. Inability to undergo implantation of gold fiducial markers or rectal spacer gel. 11\. Patients with a prior or concurrent malignancy whose natural history or treatment has the potential to interfere with the safety or efficacy assessment of the investigational regimen.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Charleston?

Yes, this clinical trial (NCT07325721) has an active research site in Charleston, SC that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Prostate Cancer Treatment Options in Charleston, SC

If you're searching for prostate cancer treatment options in Charleston, SC, this clinical trial (NCT07325721) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Charleston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced prostate cancer specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all prostate cancer clinical trials near you to find additional studies recruiting in your area.

Prostate Cancer Clinical Trial in Charleston, SC

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