Is NCT06826924 recruiting in Baltimore, MD?

Yes, NCT06826924 is currently enrolling participants at its Baltimore, MD location. This prostate cancer clinical trial is accepting qualified participants.

How do I join the prostate cancer clinical trial in Baltimore?

To join this clinical trial in Baltimore, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Baltimore clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Prostate Cancer Clinical Trial in Baltimore, MD

About This Prostate Cancer Study in Baltimore

Activating the immune system to kill cancer cells is a promising therapeutic strategy for some patients with cancer. Unfortunately, current immune-targeting treatments do not work for patients with prostate cancer. In animal models of cancer, fasting can reprogram the body's metabolism and immune cell function to help immune cells kill cancer cells likely by increasing ketosis. The purpose of this study is to determine whether 7 days of water-only fasting or a ketogenic very low-calorie diet or ketone supplementation is safe and feasible for patients with prostate cancer. This will help the investigators develop future studies to test whether incorporating periods of fasting or very low calorie diets or a ketone supplement into treatment plans for prostate cancer can improve outcomes from this disease.

Sponsor: Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins

Who Can Participate

Inclusion Criteria

Eastern Cooperative Oncology Group (ECOG) Performance Status 0 or 1

Age ≥18 years

Diagnosis of adenocarcinoma of the prostate

If a soft tissue metastasis amenable to biopsy is present, then the participant must agree to biopsies.

If the participant has local prostate cancer, then the participant must agree to prostate biopsy or radical prostatectomy on days 8, 9, or 10. -. Prostate-specific antigen (PSA) is not currently declining, as determined by most recent 2 measurements taken at least 1 week apart in previous 2 months.

BMI between 20 and 35 kg/m2

Prior treatment with any prostate cancer therapy is permitted if \>2 weeks from last dose. Patients are not required to have received prior treatment for prostate cancer.

Prior treatment with steroids is permitted if \>2 weeks from last dose. Patients who cannot be weaned off steroids are not eligible.

Acceptable liver function:

Bilirubin \< 2.5 times institutional upper limit of normal (ULN)

Aspartate transaminase (AST) (SGOT) and Alanine transaminase (ALT) (SGPT) \< 2.5 times ULN

Acceptable renal function: glomerular filtration rate (GFR) of 50 mL/min/1.73 m2 or higher. GFR will be estimated by the 2021 chronic kidney disease epidemiology (CKD-EPI) creatinine equation1 using the online calculator found on UpToDate.

Acceptable hematologic status:

Absolute neutrophil count (ANC) ≥ 1500 cells/mm3 (1.5 ×109/L)

Platelet count ≥ 100,000 platelet/mm3 (100 ×109/L)

Hemoglobin ≥ 8 g/dL.

Acceptable electrolyte and acid/base status:

Sodium 135-148 millimoles (mM)

Potassium 3.5-5.1mM

Carbon Dioxide 21-31mM

Phosphorus 2.7-4.5mM

Magnesium ≥1.6mM

Lactate ≤2mM

Ability to understand and willingness to sign a written informed consent document

Exclusion Criteria

ECOG Performance status ≥2

Unintentional weight loss greater than or equal to 5% in previous 3 months

Diabetes mellitus, defined as HbA1c ≥6.5% or use of medications for diabetes

Active uncontrolled infection. Patients with a history of HIV/AIDS may be eligible if CD4+ T cell counts are ≥ 350 cell/ul, the patients have had no opportunistic infection within the past 12 months, they have been on established antiretroviral therapy (ART) for at least four weeks, and the HIV viral load is less than 400 copies/ml prior to enrollment. Patients with a history of hepatitis C virus (HCV) infection are eligible if the patients have completed curative antiviral treatment and the HCV viral load is below the limit of quantification.

Use of immunosuppressive medications including steroids

Use of diuretics or beta blockers

History of cardiac arrythmia, myocardial infarction, valvular heart disease, or pulmonary hypertension

Abnormal screening EKG

Daily alcohol consumption

Any condition or mental impairment that may compromise the ability to give informed consent, patient's safety or compliance with study requirements as determined by the investigator

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Baltimore?

Yes, this clinical trial (NCT06826924) has an active research site in Baltimore, MD that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Prostate Cancer Treatment Options in Baltimore, MD

If you're searching for prostate cancer treatment options in Baltimore, MD, this clinical trial (NCT06826924) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Baltimore research site is actively enrolling participants for this clinical trial. You'll receive care from experienced prostate cancer specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all prostate cancer clinical trials near you to find additional studies recruiting in your area.

Prostate Cancer Clinical Trial in Baltimore, MD

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