Detroit, MINCT06297499Now EnrollingIRB Ready

Pruritus Caused by Drug Clinical Trial in Detroit, MI

Access cutting-edge pruritus caused by drug treatment through this clinical trial at a research site in Detroit. Study-provided care at no cost to qualified participants.

Sponsored by Wayne State University

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Expert Care in Detroit

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IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related pruritus caused by drug treatment provided free

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Why Participate?

  • No-Cost Study Care

  • Local to Detroit

    Convenient for MI residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Detroit site if eligible
  4. 4Begin participation

About This Pruritus Caused by Drug Study in Detroit

Opioids are often added with a local anesthetic to enhance the duration and quality of spinal anesthesia for cesarean delivery patients. However, spinal opioids are associated with a wide variety of side effects such as nausea, vomiting, (N/V) and pruritus (itching). The occurrence of pruritus can vary between 30% and 100% making pruritus the most common side-effect of intrathecal opioids and this rate is even higher in pregnant patients. Pruritus may require treatment which can be ineffective or sometimes reverse the analgesic effect of the opioids. Ondansetron is a safe and very commonly used Serotonin receptor antagonist treatment for local anesthetic opioid-induced pruritus used in pregnancy. The effect of different administration times of ondansetron in reducing pruritus or N/V in cesarean section (CS) cases has not been extensively studied and thus, this prospective study can help guide future clinical management of side effects caused by spinal intrathecal morphine administration.

Sponsor: Wayne State University

Who Can Participate

Inclusion Criteria

American Society of Anesthesiologists (ASA) physical status 1-3
Adult parturient (18 -50 years of age) scheduled to undergo elective cesarean delivery under spinal anesthesia
Patients must be willing and cognitively able to give written informed study consent

Exclusion Criteria

Patients with an ASA physiological assessment greater than grade 3
Allergies to local anesthetics, opioids, or ondansetron
Coagulopathies precluding provision of spinal anesthesia
Pre-eclampsia with severe features
Pre-intrathecal pruritus
Psychiatric or language deficiencies affecting assessment of pain
Insufficient understanding of the pain scoring system
Patients who receive any other regional anesthesia techniques
Patients on higher than a 100mg of daily morphine equivalent
Cardiac issues that would preclude spinal anesthesia (Congestive heart failure, Mitral or Aortic valve pathology.
Confounding neural issues that would preclude spinal anesthesia.
Coadministration of drugs that would potentially interact with ondansetron. Including Apomorphine, Phenytoin, Carbamazepine, Rifampicin, Tramadol and Chemotherapy drugs.
Coadministration of drugs that would potentially prolong QTc interval. Including Antiarrhythmic, Antidepressants, Antipsychotics, and the following list of medications. a. Levofloxacin, Ciprofloxacin, Gatifloxacin, Moxifloxacin, Clarithromycin, Erythromycin, Ketoconazole, Itraconazole, Cisapride, Sumatriptan, Zolmitriptan, Arsenic, Dolasetron, Methadone
Coadministration of drugs that would potentially lead to the development of serotonin syndrome. Including the following: a. Selective serotonin reuptake inhibitors, Serotonin and norepinephrine reuptake inhibitors, antidepressants, carbamazepine , valproic acid, triptans, Chronic pain medications prior to procedure (Fentanyl, Hydrocodone, Meperidine, Oxycodone, tramadol),Lithium, dextromethorphan, Linezolid and Ritonavir
Patients having the following
Patients known to have hypersensitivity (e.g., anaphylaxis) to ondansetron or any components of the formulation
Concomitant use of apomorphine
History of QTc interval prolongation (QTc \>440) and Torsade de Pointes
Serotonin syndrome
Phenylketonuric patients
Concurrent use of selective serotonin reuptake inhibitors (SSRIs) and serotonin and noradrenaline reuptake inhibitors (SNRIs)

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Detroit?

Yes, this clinical trial (NCT06297499) has an active research site in Detroit, MI that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Pruritus Caused by Drug Treatment Options in Detroit, MI

If you're searching for pruritus caused by drug treatment options in Detroit, MI, this clinical trial (NCT06297499) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Detroit research site is actively enrolling participants for this clinical trial. You'll receive care from experienced pruritus caused by drug specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all pruritus caused by drug clinical trials near you to find additional studies recruiting in your area.

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