Induction of Dreaming With EEG and Anesthesia for Post-traumatic Stress Disorder

Inclusion criteria

• A subject will be eligible for inclusion when all of the following criteria are met:
• Male or female, 18 to 70 years of age
• Able to read, understand, and provide written, dated informed consent prior to screening.
• Diagnosed with PTSD prior to screening, according to the criteria defined in the Diagnosis and Statistical Manual of Mental Disorders, Fifth Edition. The diagnosis of PTSD will be made by a trained study staff member and supported by the Structured Clinical Interview for DSM Disorders (SCID).
• Meet the threshold of CAPS-5 score of \>20 during screening.
• In sufficiently good health to proceed with a low-risk elective procedure, characterized using the American Society of Anesthesiologists (ASA) physical status classification system as Class I or II.
• If female, a status of non-childbearing potential or use of an acceptable form of birth control
• Body mass index between 17-35 kg/m2.

Exclusion criteria

• A potential participant will NOT be eligible for participation if any of the following criteria are met:
• Female who is pregnant or breastfeeding.
• Total CAPS-5 score ≤20 at either the screening.
• Current diagnosis of a Substance Use Disorder (SUD; Abuse or Dependence, as defined by DSM-V) rated "moderate" or "severe" per criteria of the SCID, or Alcohol Use Disorder rated "moderate" or "severe" per SCID criteria. The following categories of SUD will NOT be excluded: nicotine dependence; alcohol or substance use disorder rated "mild"; alcohol or substance use disorder of any severity in remission, either early (3-12 months) or sustained (\>12 months) time frames.
• Current diagnosis of Axis I disorders other than Dysthymic Disorder, Generalized Anxiety Disorder, Social Anxiety Disorder, Panic Disorder, Agoraphobia, Specific Phobia, or Bipolar II Disorder (unless one of these is comorbid and clinically unstable, and/or the focus of the participant's treatment for the past six months or more)
• History of schizophrenia or schizoaffective disorders, or any history of psychotic symptoms in the current or previous depressive episodes.
• History of anorexia nervosa, bulimia nervosa, or eating disorder not otherwise specified, within five years of screening.
• Any Axis I or Axis II Disorder, which at screening is clinically predominant to their PTSD or has been predominant to their PTSD at any time within six months prior to screening.
• In the judgment of the investigator, the subject is at significant risk for suicidal behavior during the course of his/her participation in the study.
• A neurological disorder
• A cardiovascular disorder
• A pulmonary/respiratory disorder
• Clinically significant liver disease
• Clinically significant kidney disease
• Symptomatic gastroesophageal reflux disease, hiatal hernia, or other gastrointestinal disorder placing patient at risk for aspiration or that would merit categorization of patient as ASA Class III or higher
• An endocrine disorder
• Any other abnormal laboratory result at the time of the screening exam that in the view of the investigator poses a risk for participation in the study.
• If, in the view of the participant's current primary mental health care provider this study poses a risk for participation (if a participant has a current mental health care provider).
• Participation in any clinical trial with an investigational drug or device that conflicts with this trial, within the past month or concurrent to study participation.