Is NCT04871607 recruiting in Duarte, CA?

Yes, NCT04871607 is currently recruiting participants at its Duarte, CA location. This recurrent hodgkin lymphoma clinical trial is actively enrolling qualified participants.

How do I join the recurrent hodgkin lymphoma clinical trial in Duarte?

To join this clinical trial in Duarte, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this Duarte clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Recurrent Hodgkin Lymphoma Clinical Trial in Duarte, CA

About This Recurrent Hodgkin Lymphoma Study in Duarte

This phase II trials studies the effects of yttrium-90 labeled anti-CD25 monoclonal antibody combined with BEAM chemotherapy conditioning in treating patients with Hodgkin lymphoma that does not response to treatment (refractory) or has come back (relapsed). Yttrium-90-labeled anti-CD25 is an antibody (proteins made by the immune system to fight infections) that is attached to a radioactive substance and may kill cancer cells and shrink tumors. Chemotherapy drugs, such as carmustine, etoposide, cytarabine, and melphalan, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. Giving chemotherapy before a peripheral blood stem cell transplant helps kill cancer cells in the body and helps make room in the patient's bone marrow for new blood-forming cells (stem cells) to grow.

Sponsor: City of Hope Medical Center

Who Can Participate

Inclusion Criteria

Informed Consent and Willingness to Participate 1. Documented informed consent of the participant and/or legally authorized representative. \- Assent, when appropriate, will be obtained per institutional guidelines Age Criteria, Performance status

Age: ≥18 years

Karnofsky performance status ≥ 70%

Life expectancy ≥ 6 months Nature of Illness and Illness Related Criteria

Histologically confirmed HL

High risk relapsed or refractory HL disease defined as having any one of the following:

B symptoms at relapse

Extranodal disease at relapse

Primary refractory disease'

Relapse \< 1 year after completion of frontline therapy

Not in CR at the time of transplant

Relapse after receiving PD1 blockade or brentuximab vedotin as initial therapy

Patients will be enrolled after collection of at least 2.0 x 106 CD34 cells/kg of autologous hematopoietic progenitor cells (HPC-A) by apheresis.

Recovery from non-hematologic toxicities of salvage cytoreductive chemotherapy to ≤ grade 2 (CTCAE v5). Clinical Laboratory and Organ Function Criteria (To be performed prior to Day 1 of protocol therapy)

Serum creatinine ≤ 1.5 mg/dL

Creatinine clearance of ≥ 60 mL/min per 24 hour urine test

Total bilirubin ≤ 1.5 X ULN (unless has Gilbert's disease)

AST/SGOT ≤1.5 x ULN (except in cases where abnormal LFTs are due to involvement with HL)

ALT/SGPT ≤ 1.5 x ULN (except in cases where abnormal LFTs are due to involvement with HL)

Left ventricular ejection fraction (LVEF) ≥ 50%

FEV1 \> 65% of predicted measured, or DLCO (diffusion capacity) ≥ 50% of predicted measured (corrected for hemoglobin). Contraception

Agreement by females and males of childbearing potential\

to use an effective method of birth control or abstain from heterosexual activity for the course of the study through at least six months after the last dose of protocol therapy.

Childbearing potential defined as not being surgically sterilized (men and women) or have not been free from menses for \> 1 year (women only).

Exclusion Criteria

Prior and concomitant therapies

Planned BV consolidation after AHCT

Prior high dose chemotherapy with autologous stem cell transplant, or prior allogeneic transplantation.

Significant prior external beam dose-limiting radiation to a critical organ based on review of the prior radiation treatment records by the Radiation Oncology PI.

Patients may not be receiving any other investigational agents, or concurrent biological, chemotherapy, or radiation therapy. Other illnesses or conditions

Myelodysplasia or any active malignancy other than HL, or \< 5 years remission from any other prior malignancy, except non-melanoma skin cancer, localized prostate cancer or localized cervical cancer

Any cytogenetic abnormality in the bone marrow that is known to be associated with or predictive of myelodysplasia is excluded. This includes, but is not limited to, del(5), del(7), del(11).

Lymphocyte-predominant Hodgkin Lymphoma

History of allergic reactions attributed to compounds of similar chemical or biologic composition to 90Y-basiliximab-DOTA.

Persistent marrow involvement (\>10%) with HL after salvage cytoreductive therapy and before stem cell mobilization.

BM harvest required to reach adequate cell dose for transplant.

Active Hepatitis B or C viral infection or Hepatitis B surface antigen positive

Positive Human Immunodeficiency Virus antibody, patients with undetectable HIV viral load with CD4 ≥ 300 and are on HAART medication are allowed

Patients should not have any uncontrolled illness including ongoing or active infection.

Patients with psychosocial circumstances or illnesses that preclude protocol participation (to be determined by P.I.)

Pregnant women are excluded from this study because 90Y-basiliximab/DOTA is an agent with the potential for teratogenic or abortifacient effects. Because there is an unknown but potential risk for adverse events in nursing infants secondary to treatment of the mother 90Y-basiliximab/DOTA, breastfeeding should be discontinued if the mother is treated with 90Y-basiliximab/DOTA.

Any other condition that would, in the Investigator's judgment, contraindicate the patient's participation in the clinical study due to safety concerns with clinical study procedures. Noncompliance

Prospective participants who, in the opinion of the investigator, may not be able to comply with all study procedures (including compliance issues related to feasibility/logistics).

Eligibility should be confirmed per institutional policies.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Duarte?

Yes, this clinical trial (NCT04871607) has an active research site in Duarte, CA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Recurrent Hodgkin Lymphoma Treatment Options in Duarte, CA

If you're searching for recurrent hodgkin lymphoma treatment options in Duarte, CA, this clinical trial (NCT04871607) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Duarte research site is actively enrolling participants for this phase 2 clinical trial. You'll receive care from experienced recurrent hodgkin lymphoma specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all recurrent hodgkin lymphoma clinical trials near you to find additional studies recruiting in your area.

Recurrent Hodgkin Lymphoma Clinical Trial in Duarte, CA

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