Wilmington, DENCT07070895Now EnrollingIRB Ready

Refractory Chronic Cough Clinical Trial in Wilmington, DE

Access cutting-edge refractory chronic cough treatment through this clinical trial at a research site in Wilmington. Study-provided care at no cost to qualified participants.

Sponsored by Hyfe Inc

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Expert Care in Wilmington

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IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related refractory chronic cough treatment provided free

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Check if you qualify for this refractory chronic cough clinical trial in Wilmington, DE

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Why Participate?

  • No-Cost Study Care

  • Local to Wilmington

    Convenient for DE residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Wilmington site if eligible
  4. 4Begin participation

About This Refractory Chronic Cough Study in Wilmington

The goal of this single-cohort clinical trial is to learn whether a smartphone-based Cough Management (CM) program can reduce cough frequency and burden in adults (21-80 years) who have refractory or unexplained chronic cough.  The main questions it aims to answer are: * Does four weeks of using the CM feature in the CoughPro app lower objective cough rate (coughs per hour) compared with each participant's one-week baseline?  * Does the program also lessen cough intensity (bout metrics) and improve patient-reported quality-of-life scores on the Leicester Cough Questionnaire and PGI-S? Participants will: * Wear a Hyfe CoughMonitor smartwatch continuously for 6 weeks (1-week baseline, 4-week intervention, 1-week follow-up), charging it nightly.  * Complete science-based in-app CM lessons based on behavioral cough-suppression therapy and practice the techniques during the 4-week intervention. * Fill out online questionnaires (LCQ and PGI-S) at baseline and at the end of Week 4. * Join a brief exit interview, then return the smartwatch and receive a compensation voucher.

Sponsor: Hyfe Inc

Who Can Participate

Inclusion Criteria

Age 21 or older.
Currently suffering from a cough that started at least 8 weeks ago that is largely unproductive (i.e., at least 50% of the time the cough produces zero mucus that needs to be spit out or swallowed).
Normal chest X-ray or chest CT scan at some point that was prescribed specifically for their cough.
At least one physician visit for cough with standard-of-care therapy but inadequate symptom relief.
Stability of treatment: willing to avoid new cough treatments during study or report changes if they occur.
Ability to comply: willing/able to wear the watch daily for the required duration of study and to complete all required questionnaires.
Informed consent: understanding of the study procedures and agreement to comply with protocol.

Exclusion Criteria

Recent upper respiratory infection (past 4 weeks).
History of hemoptysis (coughing up blood) since onset of the current cough.
Current smoker (incl. vaping) of any substance.
≥10 consecutive pack-years smoking history within \<10 years prior to screening.
Diagnosed with a chronic lung condition (COPD, emphysema, lung cancer, IPF, chronic bronchitis, asthma). Note: Suspected asthma without confirmed diagnosis or benefit from asthma therapy is not an exclusion.
Current or past head/neck cancer.
Difficulty swallowing.
On ACE inhibitors, such as Benzapril (Lotensin), Captopril (Capoten), Enalapril/Enalaprilat (Vasotec oral and injectable), Fosinopril (Monopril), Lisinopril (Zestril and Prinivil), Moexipril (Univasc), Perindopril (Aceon), Quinapril (Accupril), Ramipril (Altace), and Trandolapril (Mavik)
Prior treatment for cough by a speech-language pathologist.
Living with another individual with a frequent cough that would interfere with monitoring.
Participation in any cough intervention study within 30 days or 5 half-lives of the intervention.
Major scheduled surgery during the study period.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Wilmington?

Yes, this clinical trial (NCT07070895) has an active research site in Wilmington, DE that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Refractory Chronic Cough Treatment Options in Wilmington, DE

If you're searching for refractory chronic cough treatment options in Wilmington, DE, this clinical trial (NCT07070895) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Wilmington research site is actively enrolling participants for this clinical trial. You'll receive care from experienced refractory chronic cough specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all refractory chronic cough clinical trials near you to find additional studies recruiting in your area.

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