Bloomington, INNCT07030725Now EnrollingIRB Ready

Regulation of Energy Expenditure Clinical Trial in Bloomington, IN

Access cutting-edge regulation of energy expenditure treatment through this clinical trial at a research site in Bloomington. Study-provided care at no cost to qualified participants.

Sponsored by Indiana University

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IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related regulation of energy expenditure treatment provided free

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Why Participate?

  • No-Cost Study Care

  • Local to Bloomington

    Convenient for IN residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Bloomington site if eligible
  4. 4Begin participation

About This Regulation of Energy Expenditure Study in Bloomington

Brown adipose tissue becomes activated during cold conditions to increase thermogenesis (i.e., energy expenditure). Topical menthol application increases resting energy expenditure but it is unclear whether brown adipose tissue activation contributes to this rise in the energy expenditure. The overall goal with this project is to determine whether topical menthol application stimulates brown adipose tissue.

Sponsor: Indiana University

Who Can Participate

Inclusion Criteria

Fluency in English
Participate in 150 minutes or more of at least moderate intensity exercise per week during the previous year. Assessment of moderate intensity physical activity will be determined via the International Physical Activity Questionnaire (i.e., IPAQ) (described in detail in Section 7.0). This questionnaire defines moderate intensity exercise as "activities that take moderate physical effort and make you breathe somewhat harder than normal".
Body fat ≤ 30% as determined by DEXA scan
Be cleared for physical activity according to the 2020 Physical Activity Readiness Questionnnaire (PAR-Q+).

Exclusion Criteria

Any autonomic cardiovascular, metabolic, neurologic, endocrine, or respiratory disease, that, in the opinion of the investigator, would exclude them from participation.
Previously diagnosed liver and/or kidney dysfunction, including, but not limited to, acute and/or chronic kidney disease, cirrhosis, hepatitis, and fatty liver disease.
Women who are pregnant or breastfeeding.
Current use of tobacco or electronic cigarette, or regular (i.e., more than twice a week) use within the last 1 year.
History of peripheral cold injury, skin disorder (eczema, psoriasis), or excessive tattooing.
Known chronic (i.e., cancer, surgery) or acute conditions (i.e., diarrhea, constipation) of the rectum.
Menthol allergy (described in detail in Section 7.0 and 9.0). Menthol can cause skin irritation when applied topically, especially for people with sensitive skin or allergies. For this reason, recruited participants will be screened for a menthol allergy during the informed consent/screening visit. We will apply a small quantity of the cream (\~2ml) to an isolated body area to limit skin exposure. In the case a rash develops during the application of the cream, research staff will irrigate the area to remove the substance and limit further exposure. A 24-hour follow-up phone call initiated by research staff will be implemented to follow-up on all adverse reactions. Detectable BAT activation during a localized cold stress test (i.e., face cooling test) (procedure described in detail in Section 7.0).
Using medications with direct effects on the cardiovascular system including, but not limited to:
Anticoagulants.
Antiplatelet agents.
ACE Inhibitors.
Angiotensin II receptor blockers.
Angiotensin-receptor neprilysin inhibitors.
Beta blockers.
Calcium, potassium, or sodium channel blockers.
Cholesterol lowering medications.
Digitalis preparations.
Vasodilators.
Anticholinergics.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Bloomington?

Yes, this clinical trial (NCT07030725) has an active research site in Bloomington, IN that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Regulation of Energy Expenditure Treatment Options in Bloomington, IN

If you're searching for regulation of energy expenditure treatment options in Bloomington, IN, this clinical trial (NCT07030725) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Bloomington research site is actively enrolling participants for this clinical trial. You'll receive care from experienced regulation of energy expenditure specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all regulation of energy expenditure clinical trials near you to find additional studies recruiting in your area.

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