St Louis, MONCT05880914Now EnrollingIRB Ready

Renal Osteodystrophy Clinical Trial in St Louis, MO

Access cutting-edge renal osteodystrophy treatment through this clinical trial at a research site in St Louis. Study-provided care at no cost to qualified participants.

Sponsored by Thomas Nickolas

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Expert Care in St Louis

Access renal osteodystrophy specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related renal osteodystrophy treatment provided free

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Check if you qualify for this renal osteodystrophy clinical trial in St Louis, MO

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to St Louis

    Convenient for MO residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit St Louis site if eligible
  4. 4Begin participation

About This Renal Osteodystrophy Study in St Louis

Treatment of renal osteodystrophy is impeded by the lack of practical and accurate tools to determine underlying bone turnover. Gold standard bone biopsy is not practical in the clinic for the vast majority of kidney disease patients and parathyroid hormone and bone alkaline phosphatase have insufficient accuracy for turnover type to safely and confidently guide treatment of renal osteodystrophy. In the present investigation, the investigators will study a microRNA approach as a novel non-invasive biomarker of turnover for renal osteodystrophy.

Sponsor: Thomas Nickolas

Who Can Participate

Inclusion Criteria

Study participant has provided informed consent
Age ≥ 18 years
CKD Stages 3-5D regardless of kidney transplantation status
CKD5D patients receiving maintenance hemodialysis for at least 3 months
Clinically indicated treatment for renal hyperparathyroidism, renal osteodystrophy and/or Osteoporosis
PTH, BSAP and CTX meets defined thresholds for low or high turnover ROD type or a Bone biopsy evidence of low or high turnover based

Exclusion Criteria

Currently receiving treatment in an investigational device or drug study, or less than 30 days since ending treatment on an investigational device or drug study(s)
Currently receiving investigational procedures/drugs from another study while participating in this study
Use of etelcalcetide, bisphosphonate, denosumab, teriparatide, abaloparatide or romosozumab during the 6 months prior to study enrollment; however, participant can be included if being treated with bone active agent but will have class change to an agent that will result in a change in bone turnover from low to high or high to low
New use of cinacalcet over the prior 6 months
Use of Zoledronic Acid (Reclast) less than 24 months from study enrollment for patients with eGFR \<30mL/minute
Anticipated or scheduled kidney transplant during the study period or less than 1 year from receiving a kidney transplant
For patients with a solid organ transplant, less than 1 year from receiving the transplant
Patient has an unstable medical condition based on medical history, physical examination, and routine laboratory tests, or is otherwise unstable in the judgment of the Investigator
Metabolic bone diseases not related to the kidney (e.g., Paget's, Osteogenesis Imperfecta)
Endocrinopathy (e.g., untreated hyperthyroidism)
Malignancy within the last 5 years (except non-melanoma skin cancers or cervical carcinoma in situ)
Patient is pregnant or nursing
Weight \>300 pounds (scanner limitation)
Allergy to tetracycline or demeclocycline
Patients on non-aspirin anticoagulants that cannot be reasonably held for biopsy
Patient unable to complete all protocol-required study visits or procedures, and/or to comply with all required study procedures to the best of the patient and Investigator's knowledge

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in St Louis?

Yes, this clinical trial (NCT05880914) has an active research site in St Louis, MO that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Renal Osteodystrophy Treatment Options in St Louis, MO

If you're searching for renal osteodystrophy treatment options in St Louis, MO, this clinical trial (NCT05880914) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our St Louis research site is actively enrolling participants for this clinical trial. You'll receive care from experienced renal osteodystrophy specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all renal osteodystrophy clinical trials near you to find additional studies recruiting in your area.

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