NCT03932786 · Vanderbilt-Ingram Cancer Center
Studying Health Outcomes After Treatment in Patients With Retinoblastoma
(RIVERBOAT)
What this study is about
This trial studies health outcomes after treatment in patients with retinoblastoma. Gathering health information over time from patients and family members through vision assessments, samples of tissue and saliva, and questionnaires may help doctors learn more about what causes retinoblastoma, identify long-term health outcomes for patients with retinoblastoma, and find out which therapies may be the best for treating retinoblastoma
View original scientific description
This trial studies health outcomes after treatment in patients with retinoblastoma.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Unilateral or bilateral intraocular retinoblastoma
- Diagnosis between the ages of 0 - 17.99 years
- Diagnosis on or after January 1, 2008
- No exclusions based on primary or secondary treatment modalities
- Retrospective group patients must be ≥ 6 months post end of treatment at study entry
- For those already at this timepoint, they are now eligible
- For those in treatment, or otherwise not yet at this timepoint, they are eligible once at they are ≥ 6 months post end of treatment
- Prospective group patients must not have begun treatment
- Patients with diminished capacity will not be enrolled.
- Language: Patients must be able to communicate in English, French, or Spanish
- Sibling Cohort: One sibling, not affected by retinoblastoma will be enrolled, preference for the sibling closest in age to the RB patient.
- Regulatory Requirements: All patients and/or their parents or legal guardians must sign a written informed consent. All institutional, FDA, and NCI requirements for human studies must be met.
Exclusion criteria
- based on primary or secondary treatment modalities
- Retrospective group patients must be ≥ 6 months post end of treatment at study entry
- For those already at this timepoint, they are now eligible
- For those in treatment, or otherwise not yet at this timepoint, they are eligible once at they are ≥ 6 months post end of treatment
- Prospective group patients must not have begun treatment
- Patients with diminished capacity will not be enrolled.
- Language: Patients must be able to communicate in English, French, or Spanish
- Sibling Cohort: One sibling, not affected by retinoblastoma will be enrolled, preference for the sibling closest in age to the RB patient.
- Regulatory Requirements: All patients and/or their parents or legal guardians must sign a written informed consent. All institutional, FDA, and NCI requirements for human studies must be met.
Where
- Chicago, Illinois
- Minneapolis, Minnesota
- St Louis, Missouri
- Cincinnati, Ohio
- Philadelphia, Pennsylvania
- Nashville, Tennessee
- Houston, Texas
- Milwaukee, Wisconsin
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Sep 19, 2025 · Source of record for eligibility and locations