NCT04402086 · Yale University
Rheumatology Patient Registry and Biorepository
What this study is about
To facilitate clinical, basic science, and translational research projects involving the study of rheumatic diseases.
View original scientific description
To facilitate clinical, basic science, and translational research projects involving the study of rheumatic diseases.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- for Rheumatology Patients:
- Patients ≥18 years old with a diagnosis of a rheumatic autoimmune disease including, but not limited to: adult onset Still's disease, ankylosing spondylitis, antiphospholipid syndrome, Behcet's disease, dermatomyositis, giant cell arteritis, mixed connective tissue disease, polymyalgia rheumatica, polymyositis, psoriatic arthritis, reactive arthritis, rheumatoid arthritis, sarcoidosis, scleroderma, Sjogren's syndrome, systemic lupus erythematosus, undifferentiated connective tissue disease and vasculitis.
- Receiving clinical care at Yale Rheumatology clinics
Exclusion criteria
- for Rheumatology Patients:
- Unable to provide informed consent
- No patients will be excluded based on gender or ethnicity or pregnancy status.
- Women who are currently pregnant will need to wait to donate a skin biopsy until after they deliver.
- Patients allergic to lidocaine or epinephrine or have a history of impaired wound healing will not be able to donate a skin biopsy. Inclusion Criteria for Healthy Volunteers:
- Age ≥ 18 years old
- No chronic skin conditions
- No diagnosis of a rheumatic autoimmune disease (e.g., lupus, rheumatoid arthritis)
- Normal BMI Exclusion Criteria for Healthy Volunteers:
- Unable to provide informed consent.
- Currently pregnant or nursing unless the study goal is to study pregnant or nursing woman.
- Allergies to lidocaine or epinephrine (skin biopsies).
- A history of impaired wound healing (skin biopsies).
Where
- New Haven, Connecticut
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Feb 13, 2026 · Source of record for eligibility and locations