Baton Rouge, LANCT04047849Now EnrollingIRB Ready

Rupture of Membranes; Delayed Delivery (Following Spontaneous Rupture) Clinical Trial in Baton Rouge, LA

Access cutting-edge rupture of membranes; delayed delivery (following spontaneous rupture) treatment through this clinical trial at a research site in Baton Rouge. Study-provided care at no cost to qualified participants.

Sponsored by Woman's

Quick Self-Assessment

See if you qualify for this Baton Rouge location

Preparing your pre-screening questions…

Expert Care in Baton Rouge

Access rupture of membranes; delayed delivery (following spontaneous rupture) specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related rupture of membranes; delayed delivery (following spontaneous rupture) treatment provided free

Apply for This Baton Rouge Location

Check if you qualify for this rupture of membranes; delayed delivery (following spontaneous rupture) clinical trial in Baton Rouge, LA

Secure & Confidential

Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Baton Rouge

    Convenient for LA residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Baton Rouge site if eligible
  4. 4Begin participation

About This Rupture of Membranes; Delayed Delivery (Following Spontaneous Rupture) Study in Baton Rouge

This study is a non-blinded, prospective, randomized controlled trial designed to compare the effect of outpatient oral antibiotics (i.e., amoxicillin and azithromycin) on the length of time (days) that pregnancy continues after a patient's water bag has ruptured prematurely. If a patient has been diagnosed with rupture of their water bag between 18 0/7 weeks and 22 6/7 weeks and there are no other associated complications with the pregnancy, the patient is eligible for initial consideration for this study. Patients will be admitted to the hospital for a 24-hour monitoring period. If the patient remains without further complications during this monitoring period, the patient will be eligible for enrollment. If enrollment is desired, the patient will be randomly assigned to receive either antibiotics (treatment arm of the study) or no antibiotics (control arm of the study). The treatment arm will receive an outpatient, 7-day course of oral antibiotics (azithromycin and amoxicillin) with the first dose given in the hospital to ensure no side effects. The control arm will not receive outpatient antibiotics. Both groups will have weekly, office follow-up visits with high-risk pregnancy specialists to ensure no further complications. Both groups will be admitted to the hospital if the patients reach 23 0/7 weeks without complications. At this time the patients will receive all medications and therapies recommended by the governing board of OBGYNs. Subjects of both groups will also be admitted before 23 0/7 weeks if further complications noted either at their clinic follow up visits or anytime outside of the hospital. The duration of time that the patient remains pregnant after breaking of the water bag will be compared in each group. The investigators will also see if there is a difference in the number of patients able to reach 23 0/7 weeks between each group (treatment versus control).

Sponsor: Woman's

Who Can Participate

Inclusion Criteria

Singleton gestation
Gestational age of greater than 18 0/7 but less than or equal to 22 6/7
Diagnosis of prelabor premature rupture of membranes as determined by clinical examination noting either/or 1) visualization of amniotic fluid passing from the cervical canal and pooling in the vagina via sterile speculum examination, 2) a basic pH (i.e., positive nitrazine) test of vaginal fluid, 3) arborization (ferning) of dried vaginal fluid identified via microscopic examination, or 4) an amniotic fluid index (AFI) of less than 4cm
Greater than or equal to 18 years of age
Those with no known drug allergies or significant adverse reactions to azithromycin or amoxicillin
Afebrile at the time of presentation and throughout 24-hour observation period
Patient must be able to provide informed consent

Exclusion Criteria

Fetal anomalies in current pregnancy
Diabetes mellitus, including both pre-gestational and gestational
Abnormal placentation
Poor dating with dating ultrasound performed later than or equal to 20 0/7 weeks
Current subchorionic hemorrhage or current vaginal bleeding on presentation
Hypertensive disease, including pre-gestational chronic hypertension, gestational hypertension and pre-eclampsia/eclampsia
History of amniocentesis during this pregnancy
History of cervical incompetence, history of cerclage in previous pregnancy or current cerclage in place
Current documented urinary tract infection or bacteriuria
Current documented genital tract infection (Chlamydia, gonorrhea, or trichomonas)
Immunocompromised (i.e., HIV positive, daily steroid use, or a history of autoimmune disease for which the patient is currently undergoing treatment with immunotherapy medication)

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Baton Rouge?

Yes, this clinical trial (NCT04047849) has an active research site in Baton Rouge, LA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Rupture of Membranes; Delayed Delivery (Following Spontaneous Rupture) Treatment Options in Baton Rouge, LA

If you're searching for rupture of membranes; delayed delivery (following spontaneous rupture) treatment options in Baton Rouge, LA, this clinical trial (NCT04047849) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Baton Rouge research site is actively enrolling participants for this clinical trial. You'll receive care from experienced rupture of membranes; delayed delivery (following spontaneous rupture) specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all rupture of membranes; delayed delivery (following spontaneous rupture) clinical trials near you to find additional studies recruiting in your area.

More Rheumatoid Arthritis Trials in Baton Rouge, LA

See all rheumatoid arthritis clinical trials recruiting in Baton Rouge — not just this study.

Browse Rheumatoid Arthritis Trials in Baton Rouge

Ready to Join in Baton Rouge?

Take the first step toward participating in this groundbreaking clinical trial

Secure · Expert Care · Baton Rouge, LA