NCT03375866 · San Diego State University
Effects of Mixed Nut Consumption on Satiety and Weight Management
What this study is about
The first goal of the proposed study is to determine acute and long-term effects of mixed nuts (almonds, hazelnuts, pecans, pistachios, walnuts, and peanuts) on metabolic parameters and weight management.
View original scientific description
The first goal of the proposed study is to determine acute and long-term effects of mixed nuts (almonds, hazelnuts, pecans, pistachios, walnuts, and peanuts) on metabolic parameters and weight management. While numerous studies have shown the beneficial effects of nuts on promoting negative energy balance and weight loss, mechanistic studies exploring how the inclusion of nuts in the diet promotes a negative energy balance and weight loss have not been conducted. The second goal is to determine the mechanisms by which mixed nut consumption regulates of food intake and body weight.
Interventions
OTHER
Pretzels
Subjects consume 240 kcal of pretzels daily for 16 weeks.
OTHER
Mixed nuts
Subjects consume 240 kcal of mixed nuts daily for 16 weeks.
Primary outcome measures
Change of Satiety
Time frame: 0, 20, 40, 60, 90 and 120 minutes post snack consumption
Hunger feeling (appetite) will be examined using visual analog scale (0-10): 0 least and 10 greatest
Change of glucose level
Time frame: Baseline, 40 minutes post snack consumption, and 8 weeks and 16 weeks post daily consumption
Glucose level will be examined using glucose analysis
Change of insulin level
Time frame: Baseline, 40 minutes post snack consumption, and 8 weeks and 16 weeks post daily consumption
Insulin level will be examined using an ELISA biochemical method
Change of cholesterol levels
Time frame: 8 weeks and 16 weeks post daily consumption
Cholesterol levels will be examined using a biochemical method
Change of Lp(a)
Time frame: 8 weeks and 16 weeks post daily consumption
Lp(a) levels will be examined using an ELISA biochemical method
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- 18-55 years old
Exclusion criteria
- Pregnant woman
- Required dietary supplement use
- Required medication of metabolic disorders
- Allergy to nuts or gluten
Where
- San Diego, California
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jan 21, 2026 · Source of record for eligibility and locations