NCT07721220 · High Point University
Acute Effects of Neurodynamics on Strength and Endurance in Athletes
What this study is about
This study explores the acute effects of neurodynamics, an intervention commonly used by physical therapist to improve nerve mobility and decrease pain, on the strength and muscular endurance in the athletic population. This study aims to find if these interventions can maintain or promote strength and endurance in the hamstrings.
View original scientific description
This study explores the acute effects of neurodynamics, an intervention commonly used by physical therapist to improve nerve mobility and decrease pain, on the strength and muscular endurance in the athletic population. This study aims to find if these interventions can maintain or promote strength and endurance in the hamstrings. The studies results will help physical therapist better prescribe exercise and hands-on treatment for hamstring and sciatic nerve related conditions and injuries.
Interventions
OTHER
Sciatic Slider
Mobility of a nerve, by placing tension on one end of the nerve and slacking (removing) tension off the other side of the nerve, through a full range of motion.
OTHER
Sciatic Tensioner
Loading the nerve, by placing tension on both ends of the nerve, isometrically at end range of motion.
OTHER
Mechanically loaded neurodynamic sciatic floss
Placing tension on one end of the nerve while taking the tension off the other end, under external load of an elastic resistance band.
DEVICE
Elastic Resistance Band
Elastic resistance band was used to provide submaximal resistance during the mechanically loaded neurodynamic intervention.
Primary outcome measures
Isometric Strength
Time frame: From initial strength and endurance test, to the post intervention strength and endurance test, assessed during a single study visit, assessed up to 30 minutes.
Isometric strength of the hamstrings in knee flexion.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Participants must be between 18 and 30 years of age.
- Must be able to read, understand, and provide informed consent, in English.
- Must be currently participating in an organized sport (e.g. collegiate, club, or competitive recreational level) or engaging in structured resistance training and athletic conditioning for recreational sports events (e.g 5k, marathon, Crossfit, Hyrox, etc).
- Medically stable with no known contraindications to physical exertion.
- Cleared for participation in strength or maximal-effort isometric testing.
- Be able to perform lower extremity isometric testing without pain that limits maximal effort.
- Must have 2 lower extremities capable to producing full range knee flexion and extension range of motion.
- No medical condition that significantly alters lower extremity neuromuscular performance.
- No history of lower extremity surgery in the past 12 months.
Exclusion criteria
- Individuals younger than 18 or older than 30.
- Acute lower extremity injury in the last 12 weeks.
- Lower extremity surgery within the last 12 months.
- Pain in either lower extremity that would limit maximal physical exertion.
- History of neurological disorders, including but not limited to: Neuropathy, Stoke, MS, Parkinson's Disease, etc.
- Use of medications that significantly impact neuromuscular performance, strength or fatigue.
- No supplementation that affects neuromuscular performance, strength, or fatigue.
- Unable to read and understand English.
- Not in a vulnerable population: Pregnant, mentally or physically challenged, cognitively impaired.
Where
- High Point, North Carolina
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jul 22, 2026 · Source of record for eligibility and locations