Canton, OHNCT05856981Now EnrollingIRB Ready

Solid Tumor, Adult Clinical Trial in Canton, OH

Access cutting-edge solid tumor, adult treatment through this clinical trial at a research site in Canton. Study-provided care at no cost to qualified participants.

Sponsored by Sairopa B.V.

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Expert Care in Canton

Access solid tumor, adult specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related solid tumor, adult treatment provided free

Apply for This Canton Location

Check if you qualify for this solid tumor, adult clinical trial in Canton, OH

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Canton

    Convenient for OH residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Canton site if eligible
  4. 4Begin participation

About This Solid Tumor, Adult Study in Canton

This first-in-human, open-label, multicenter, multi-arm dose-escalation study is designed to evaluate the safety, PK, and PD of ADU-1805, an anti- SIRPα monoclonal antibody, as monotherapy and in combination with pembrolizumab (anti-PD-1 antibody).

Sponsor: Sairopa B.V.

Who Can Participate

Inclusion Criteria

Male or female aged ≥18 years
Signed and dated informed consent form
Measurable disease according to RECIST (Safety Expansion only)
ECOG Performance status of 0 or 1
Adequate organ and marrow function
Escalation Phase: Histologically and/or cytologically confirmed diagnosis of metastatic or unresectable solid tumors that are refractory to standard therapy or for which no standard therapy exists
Expansion Phase: histologically and/or cytologically confirmed diagnosis of advanced PD-(L)1-naïve MSS colorectal cancer (CRC), PD-1 relapsed/refractory patients with either advanced MSS endometrial cancer (EC), renal cell carcinoma (RCC) or non-small cell lung cancer (NSCLC) patients, and that have measurable disease according to RECIST

Exclusion Criteria

Escalation Phase: Patients that suffer from melanoma, brain tumors, glioblastoma, sarcoma and pancreatic ductal adenocarcinoma (PDAC)
Expansion Phase:
\> 3 lines of prior systemic treatments
MSS colorectal cancer (CRC): liver metastasis present
Pregnancy or breast-feeding
Prior treatment with or receipt of:
biological agents, including monoclonal antibodies and immunotherapies, within 28 days prior to the first dose of ADU-1805
chemotherapy, targeted small molecule therapy, hormonal therapy or radiation therapy within 21 days prior to the first dose of ADU-1805 and within 42 days for nitrosoureas and mitomycin C.
anti-SIRPα or anti-CD47-directed therapy
systemic chronic steroid therapy or immunosuppressive therapy within 14 days prior to the first dose of ADU-1805
other investigational new drug or investigational device within 28 days prior to the first dose of ADU-1805
vaccine containing live virus within 28 prior to the first dose of ADU-1805
Active untreated brain metastases
Active infection requiring systemic therapy
Impaired cardiac function or clinically significant cardiac disease
Current Grade \>2 toxicity related to prior anti-cancer therapy
History of drug-induced severe immune-related adverse reaction
Prior severe hypersensitivity to other monoclonal antibodies or ADU-1805 excipients
Major surgery within defined period
Diagnosis or positive test of HIV, hepatitis B, hepatitis C, or active tuberculosis
Allogenic tissue/solid organ transplant
Any intercurrent illness that is life-threatening or of such clinical significance that it would interfere with the patient's safety or ability to participate in the study

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Canton?

Yes, this clinical trial (NCT05856981) has an active research site in Canton, OH that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Solid Tumor, Adult Treatment Options in Canton, OH

If you're searching for solid tumor, adult treatment options in Canton, OH, this clinical trial (NCT05856981) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Canton research site is actively enrolling participants for this clinical trial. You'll receive care from experienced solid tumor, adult specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all solid tumor, adult clinical trials near you to find additional studies recruiting in your area.

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