New York, NYNCT07446855Now EnrollingIRB Ready

Solid Tumours Clinical Trial in New York, NY

Access cutting-edge solid tumours treatment through this clinical trial at a research site in New York. Study-provided care at no cost to qualified participants.

Sponsored by AstraZeneca

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Expert Care in New York

Access solid tumours specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related solid tumours treatment provided free

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Check if you qualify for this solid tumours clinical trial in New York, NY

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to New York

    Convenient for NY residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit New York site if eligible
  4. 4Begin participation

About This Solid Tumours Study in New York

The purpose of this modular, first trial in human study is to assess the safety, tolerability, pharmacokinetics (PK), pharmacodynamics (PD), and preliminary efficacy of ascending dose levels (DLs) of AZD4956 monotherapy and in combination with other anti-cancer agents in participants with advanced/metastatic solid tumours with homologous recombination repair (HRR) deficiencies.

Sponsor: AstraZeneca

Who Can Participate

Inclusion Criteria

Documented locally advanced or metastatic solid tumour malignancy.
Eastern cooperative oncology group (ECOG) performance status of 0 or 1 with no deterioration over the previous 2 weeks prior to screening and first day of dosing.
Minimum life expectancy ≥ 12 weeks.
Adequate organ and marrow function.
Female participants must not breastfeed and must not donate or retrieve ova for their own use from screening to approximately 6 months after the last dose of study intervention. Module 1 Inclusion Criteria:
Demonstrated evidence of disease progression.
Participants must have advanced or metastatic solid tumours.
Participants may have received up to one prior line of therapy with a poly (adenosine diphosphate-ribose) polymerase inhibitor (PARPi)-based regimen (either as a treatment or as maintenance). Module 2 Inclusion Criteria: Part A (AZD4956 in Combination with Saruparib Dose Escalation) and Part A-PD (PD Backfill Cohorts):
Participants must have one of the following conditions-
Histologically or cytologically confirmed carcinoma of the breast with recurrent locally advanced or metastatic disease and evidence of a predicted loss of function germline or somatic mutation.
Histologically or cytologically confirmed advanced ovarian, fallopian tube, or primary peritoneal cancer.
Histologically or cytologically confirmed adenocarcinoma of the prostate and advanced/metastatic castrate resistant prostate cancer (CRPC).
Histologically or cytologically confirmed advanced/metastatic pancreatic cancer.
Participants must have evaluable disease.
Participants in PD backfill cohorts must not have received prior therapy with a PARPi-based regimen (either as a treatment or as maintenance). Part A (PD Backfill Cohorts) - Participants Undergoing Paired Biopsies: \- Participants must have a tumour suitable for biopsy. Part A-Non-PD (Non-PD Backfill Cohorts) and Part B (Dose Expansion Cohorts):
Participants must have histologically or cytologically confirmed adenocarcinoma of the prostate and advanced/metastatic CRPC.
Participants must have documented metastatic disease by clear evidence of ≥ 1 bone lesion (defined as one lesion with positive uptake on bone scan) and/or ≥ 1 soft tissue lesion (measurable or non-measurable).
Participants must have received the prior approved systemic therapies for metastatic prostate cancer.
Participants must not have received prior therapy with a PARPi-based regimen (either as a treatment or as maintenance). Core

Exclusion Criteria

Any significant laboratory finding or any severe and uncontrolled medical condition.
Participants with any known predisposition to bleeding.
Spinal cord compression or symptomatic and unstable brain metastases or leptomeningeal disease.
Allogenic organ transplantation.
Known to have active infection, including hepatitis B virus (HBV) or hepatitis C virus (HCV).
Known history of infection with human immunodeficiency virus (HIV).
Active gastrointestinal disease or other condition that will interfere significantly with the swallowing, absorption, distribution, metabolism or excretion of oral therapy.
Participants with history of myelodysplastic syndrome (MDS)/acute myeloid leukaemia (AML) or with features suggestive of MDS/AML.
Participants with a known hypersensitivity to the investigational product(s) or any of the excipients of the product(s).
Previous dosing with AZD4956.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in New York?

Yes, this clinical trial (NCT07446855) has an active research site in New York, NY that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Solid Tumours Treatment Options in New York, NY

If you're searching for solid tumours treatment options in New York, NY, this clinical trial (NCT07446855) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our New York research site is actively enrolling participants for this clinical trial. You'll receive care from experienced solid tumours specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

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Secure · Expert Care · New York, NY