NCT07583498 · Zev Rymer
Spasticity in SCI Following Acute Intermittent Hypoxia
What this study is about
This study aims to observe the effects of administration of a breathing intervention (Acute Intermittent Hypoxia (AIH)) on spasticity (tightness) in individuals with incomplete Spinal Cord Injury. It is hypothesized that hypoxia will decrease the reflex threshold of the biceps brachii, indicating an increase in spasticity following the AIH.
View original scientific description
This study aims to observe the effects of administration of a breathing intervention (Acute Intermittent Hypoxia (AIH)) on spasticity (tightness) in individuals with incomplete Spinal Cord Injury. It is hypothesized that hypoxia will decrease the reflex threshold of the biceps brachii, indicating an increase in spasticity following the AIH.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Non-progressive spinal Cord injury at least 6 months prior
- Level of injury between C1-C8
- ISNCSCI ASIA classification C or D
- Measurable Spasticity
Exclusion criteria
- Pre-existing hypoxic pulmonary disease
- Positive Covid-Pneumonia diagnosis within 1 year of visit
- Uncontrolled hypertension \>140/90 mmHg
- Individuals who are currently pregnant/nursing or planning on becoming pregnant
- Individuals with a tracheostomy or who utilize mechanical ventilation
- A botulinum toxin injection to upper extremity musculature within the past 3 months
- Currently taking Baclofen
- Congestive Heart Failure
- Cardiac arrhythmias
- Uncontrolled diabetes mellitus
- Chronic obstructive pulmonary disease
- Severe Asthma
- Previous myocardial infarction
- Carotid/intracerebral artery stenosis
- Orthopedic injuries or surgeries that impact the ability to use the upper extremity
- History of Epilepsy
Where
- Chicago, Illinois
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced May 13, 2026 · Source of record for eligibility and locations