Is NCT06852469 recruiting in San Diego, CA?

Yes, NCT06852469 is currently recruiting participants at its San Diego, CA location. This stress disorders, post-traumatic clinical trial is actively enrolling qualified participants.

How do I join the stress disorders, post-traumatic clinical trial in San Diego?

To join this clinical trial in San Diego, complete the eligibility form on this page. A study coordinator will contact you to discuss next steps and determine if you qualify.

Is participation in this San Diego clinical trial free?

Yes, all study-related care is provided at no cost to qualified participants. Many studies also offer compensation for time and travel expenses.

Stress Disorders, Post-Traumatic Clinical Trial in San Diego, CA

About This Stress Disorders, Post-Traumatic Study in San Diego

A substantial majority of Veterans with posttraumatic stress disorder (PTSD) continue to suffer even with the best current medications. Progress in developing more effective medications is hampered by the substantial variability within Veterans with PTSD, meaning the most effective medication likely varies from individual to individual. New scientific tools to help identify distinct subgroups of Veterans with PTSD who are likely to respond to specific medications could help improve treatment in this population. Research has indicated that a specific subgroup of Veterans with PTSD with a high level of anxious arousal may benefit from medications which boost signaling of the neurotransmitter gamma-aminobutyric acid (GABA). This project aims to validate a clinical test to identify these individuals using new computational and neuroimaging methods combined with the medication lorazepam, a positive GABA modulator. The ultimate goal is to use these methods in future clinical trials of new medications to target the best treatments to individual Veterans with PTSD.

Sponsor: VA Office of Research and Development

Who Can Participate

Inclusion Criteria

18-65 years of age, inclusive;

Participants must be willing to abstain from alcohol 24 hours prior to and 24 hours after the testing session;

Participants must be able to participate and willing to give written informed consent and to comply with the study restrictions; Additional Inclusion Criteria for PTSD Group: (a) Current diagnosis of PTSD based on CAPS-5.

Exclusion Criteria

Has uncontrolled, clinically significant neurologic (including seizure disorders), cardiovascular, pulmonary, hepatic, renal, metabolic, gastrointestinal, urologic, immunologic, endocrine disease, or psychiatric disorder, or other abnormality, which may impact the ability of the subject to participate or potentially confound the study results;

Pregnancy (assessed by urine test at time of screening and prior to administration of study medication) or lactation;

Lifetime history of a chronic psychotic disorder or bipolar disorder type I as assessed by MINI;

Current moderate or severe substance use disorder as assessed by MINI;

Positive urine toxicology (drugs of abuse as determined by a positive urine test) at screening and before drug administration. Subjects who screen positive for THC will be given an opportunity to be included in the event of a negative urine test 2 weeks later. THC is not infrequently used for medicinal purposes and, in California, is legal for recreational use. Subjects who are positive for THC will therefore not be excluded, but will be retested to ensure that THC is unlikely to be influencing results;

Self-report or observable signs of drug or alcohol intoxication or withdrawal;

Current benzodiazepine or opioid use; other psychotropic medications are allowed as long as they are at a stable dose for at least 2 weeks and do not exhibit an unsafe interaction with the study medication;

Current or recent use of any medication deemed by the study physician (Dr. Howlett) to exhibit an unsafe interaction with lorazepam;

Past intolerance (including allergic) to lorazepam or another benzodiazepine;

Active suicidal ideation or otherwise considered at high suicidal risk by trained study staff using the C-SSRS;

History of a traumatic brain injury (TBI) resulting in loss of consciousness for more than 30 minutes;

Volunteers who do not have sufficient command of the English language, or who have any other impairment that would prevent them from reading and understanding the informed consent form(s) and completing the study procedures including clinical testing;

Any other reason why, per study physician, the subject should not participate in this study, including concomitant disease or condition that could interfere with, or for which the study drug might interfere with, the conduct of the study, or that would, in the opinion of the study physician, pose an unacceptable risk to the subject in this study. Additional Exclusion Criteria for HC Group: (a) Axis I disorder as assessed by MINI. Additional Exclusion Criteria for fMRI Participants:

Contraindication to magnetic resonance imaging.

Not right-handed as assessed by Edinburgh Handedness Inventory.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in San Diego?

Yes, this clinical trial (NCT06852469) has an active research site in San Diego, CA that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Stress Disorders, Post-Traumatic Treatment Options in San Diego, CA

If you're searching for stress disorders, post-traumatic treatment options in San Diego, CA, this clinical trial (NCT06852469) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our San Diego research site is actively enrolling participants for this phase 4 clinical trial. You'll receive care from experienced stress disorders, post-traumatic specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all stress disorders, post-traumatic clinical trials near you to find additional studies recruiting in your area.

Stress Disorders, Post-Traumatic Clinical Trial in San Diego, CA

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