NCT07218276 · University of Michigan
Passive Robots for Stroke Rehabilitation: A Feasibility Study
What this study is about
The purpose of this study is to examine the feasibility and effectiveness of a novel, multimodal approach that combines passive devices with noninvasive neuromuscular stimulation for upper extremity rehabilitation after stroke.
View original scientific description
The purpose of this study is to examine the feasibility and effectiveness of a novel, multimodal approach that combines passive devices with noninvasive neuromuscular stimulation for upper extremity rehabilitation after stroke.
Interventions
DEVICE
Functional Training with SepaRRo and NeuRRoFES
Participants will perform functional movements (e.g., reach for targets) with their extremities. During movements, the devices will be used to assist or resist their motion. Participants may receive biofeedback of their movements to better engage them in training. Participants may receive assistance from the devices (including neuromuscular stimulation) and/or their less-impaired limb.
Primary outcome measures
Device Survey For Feasibility
Time frame: Post-intervention (immediately following last session of intervention)
Subjective feedback regarding feasibility of the device for training
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Age 18 to 75 years;
- Ischemic or hemorrhagic stroke confirmed by CT, MRI, or clinical criteria;
- No major deficits of sensation or proprioception;
Exclusion criteria
- Bilateral stroke
- Unable to think clearly and remember (Mini-Mental State Exam score \< 22 and miniMOCA \< 8);
- Uncontrolled Diabetes or Hypertension;
- Severe limitations of joint range of motion that will lead to inability of testing
- Severe spasticity and joint contractures that will lead to inability of testing
- Complete paresis with no possible movements
- Severe aphasia
- Any other medical condition that will significantly impact the study results
- Unable to obtain reliable motor evoked potentials
- Are pregnant or are actively trying to conceive
- Have a recent history of repeated fainting spells or syncope.
- Have a recent history of seizure (epilepsy) while on anti-seizure medication
- Have a recent history of skull fracture/head injury
- Have metal implants in the skull
- Have cardiac pacemakers
Where
- Ann Arbor, Michigan
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Nov 10, 2025 · Source of record for eligibility and locations