NCT04829071 · University of Southern California
Cognition and Motor Learning Post-stroke
What this study is about
This project seeks to determine how post-stroke cognitive impairment moderates motor learning during walking in older adults with chronic stroke and identify brain structural markers that mediate this relationship.
View original scientific description
This project seeks to determine how post-stroke cognitive impairment moderates motor learning during walking in older adults with chronic stroke and identify brain structural markers that mediate this relationship. The chosen experimental design integrates biomechanical analyses, neuropsychological assessments, and brain imaging techniques to determine the impact of post-stroke cognitive impairment severity on two forms of motor learning (explicit and implicit) and examine the role of the dorsolateral prefrontal cortex in the relationship between cognition and explicit motor learning. Ultimately, this work may lead to the development of a more comprehensive, effective treatment approach to improve walking dysfunction in older adults post-stroke.
Interventions
BEHAVIORAL
Explicit motor learning
Participants will be provided with visual feedback of their right and left step lengths on a screen in front of a treadmill.
BEHAVIORAL
Implicit motor learning
Participants will walk on a treadmill that drives their right and left legs to move at two different speeds.
Primary outcome measures
step length asymmetry - change in performance
Time frame: Measured at three timepoints of interest within each testing session: baseline and at the beginning and end of the interventions; participants will complete 2 testing sessions over approximately 1 months
characterized as a comparison between the right and left step lengths; captured to quantify change in performance with biofeedback or split belt walking
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Unilateral stroke
- Stroke occurred more than 6 months prior
- Paresis confined to one side
- Independently ambulatory (including the use of assistive devices)
- Able to walk for 5 minutes without stopping
- Answers no to all general health questions on the PAR-Q+
- Willingness to complete study procedures
Exclusion criteria
- Brainstem or cerebellar stroke
- Aphasia (expressive, receptive, or global)
- Any major musculoskeletal or non-stroke neurological condition that interferes with the assessment of sensorimotor or cognitive function
- Metal in the head (except in the mouth), implanted cranial or thoracic devices that violate MRI safety regulations
- Uncontrolled hypertension (\>160/110mmHg)
- Concurrent physical therapy
- Claustrophobia
- Significant cognitive deficit or dementia (\<20 on MoCA)
- Inability to give informed consent
Where
- Los Angeles, California
Related conditions & keywords
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Nov 4, 2025 · Source of record for eligibility and locations