NCT05531461 · Rapid Medical
Cognition and Imaging With Tigertriever
(COGNITIVE)
What this study is about
The objective of the COGNITIVE Study is to evaluate whether successful reperfusion with Tigertriever is associated with cognitive benefit.
View original scientific description
The objective of the COGNITIVE Study is to evaluate whether successful reperfusion with Tigertriever is associated with cognitive benefit.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Patients admitted with large vessel occlusion (LVO) and treated with the Tigertriever, as indicated per the approved IFU.
- Tigertriever was used as the first line treatment in the target vessel.
- A signed informed consent.
- Age 18-75 years (inclusive).
- No known significant pre-stroke disability (pre-stroke mRS 0 or 1).
Exclusion criteria
- Use of any other IA recanalization device prior to the Tigertriever in the target vessel, including aspiration catheter.
- Evidence of acute brain hemorrhage on CT and/or MRI at admission.
- Prior hemorrhage, stroke, thrombolysis, and/or endovascular therapy in the last 3 months.
- Probable cerebral amyloid angiopathy.
- Pre-stroke diagnosed dementia and/or prescribed cholinesterase inhibitors.
- Pre-stroke diagnosed and/or currently treated major depression.
- Pre-stroke learning or intellectual disability.
- Anticipated inability to obtain 6-month follow-up assessments. \-
Where
- Los Angeles, California
- Grand Rapids, Michigan
- New York, New York
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced May 16, 2025 · Source of record for eligibility and locations