NCT07041775 · Northwestern University
MINT Conditioning to Improve Gait
What this study is about
This study will test the ability of myoelectric interface for neurorehabilitation (MINT) training to improve walking function.
View original scientific description
This study will test the ability of myoelectric interface for neurorehabilitation (MINT) training to improve walking function.
Who can participate
This study lists these criteria on ClinicalTrials.gov. A study coordinator reviews eligibility during screening — this page does not determine whether you qualify.
Inclusion criteria
- Age at enrollment is 18 to 85
- Leg impairment from unilateral stroke at least 6 months prior to screening
- Severe to moderate gait impairment (ambulatory with a maximum walking speed of 0.8 m/s, i.e., half of normal speed)
- Able to stand without assistance
- Clinically observable gait asymmetry
- Abnormal co-activation between adductor magnus and rectus femoris (R greater than or equal to 0.5)
Exclusion criteria
- Cognitive impairment with at least moderately impaired attention on digit-span test, or unable to follow instructions of the MINT task
- Visual impairment (such as hemianopia) preventing sufficient perception of the screen to play the games
- Anesthesia or severe neglect in the affected leg, or visual hemineglect (score of 2 on the NIH Stroke Scale Extinction and Inattention subtest) that impairs ability to play the games
- Participation in another study on the affected leg, or any pharmacological study, within 6 weeks of enrollment
- Inability to understand or follow commands in English due to aphasia or other reason that makes it impossible to perform the training
- Diffuse or multifocal infarcts
- Substantial leg or other pain preventing participation for 60 minutes a day
- Spasticity treatment (pharmacological or Botox) on the affected leg within past 3 months
- Severe osteoporosis causing hip or other fractures
- History of multiple falls within the last year, use of walker for balance, or falling during stance while in the lab in the first session.
- Contracture limiting the range of motion of the leg
- Current pregnancy
- From the TMS portion of the study only: History of epilepsy in adulthood requiring antiseizure medications; recent/current alcoholism or benzodiazepine/barbiturate abuse or recent history of alcohol/benzodiazepine/barbiturate withdrawal, recent history of cocaine or amphetamine use, skull fractures or skull deficits, concussion within the last 6 months, unexplained recurring headaches, vagus nerve stimulator, cochlear implant, deep brain stimulator, intracranial/carotid stents, cardiac pacemaker/AICD.
Where
- Chicago, Illinois
- Dallas, Texas
Frequently asked questions
What is a clinical trial?
A clinical trial is a research study that tests new medical treatments, drugs, devices, or procedures to determine their safety and effectiveness. Trials are carefully designed and monitored to protect participants while advancing medical knowledge.
Is it safe to participate?
Clinical trials follow strict safety guidelines and ethical standards. Trials must be reviewed and approved, and participants are closely monitored by medical professionals throughout the study. You can withdraw at any time if you choose.
Will I be compensated?
Many clinical trials offer compensation for your time, travel expenses, and inconvenience. The specific compensation varies by study and will be discussed during the screening process. All study-related medical care is typically provided at no cost to participants.
Will I receive a placebo instead of treatment?
When effective treatment exists, participants typically receive either the standard treatment plus the study intervention, or the standard treatment plus placebo. You would not be denied effective care. Placebos are primarily used when no proven treatment is available, or in addition to standard care. Your trial consent form will clearly explain what treatments you may receive.
Can I leave a trial if I change my mind?
Absolutely. Participation in clinical trials is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty or loss of benefits to which you are otherwise entitled.
How long does a clinical trial last?
Trial duration varies widely depending on the study design and purpose. Some trials last just a few weeks, while others may continue for months or years. The study coordinator will provide specific timeline information during your screening call.
Data: ClinicalTrials.gov · synced Jun 8, 2026 · Source of record for eligibility and locations