Charleston, SCNCT07050355Now EnrollingIRB Ready

Stroke Clinical Trial in Charleston, SC

Access cutting-edge stroke treatment through this clinical trial at a research site in Charleston. Study-provided care at no cost to qualified participants.

Sponsored by Medical University of South Carolina

Quick Self-Assessment

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Expert Care in Charleston

Access stroke specialists at no cost

IRB Approved

This study follows strict safety protocols and ethical guidelines

No-Cost Care

All study-related stroke treatment provided free

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Check if you qualify for this stroke clinical trial in Charleston, SC

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Your information is protected and will only be shared with the research team.

Why Participate?

  • No-Cost Study Care

  • Local to Charleston

    Convenient for SC residents

  • Cutting-Edge Treatment

    Access to innovative therapies

  • Expert Medical Care

    Close monitoring by specialists

  • Possible Compensation*

    For time and travel

*Compensation varies by study. Confirm details with coordinator.

Simple Process

  1. 1Submit this form
  2. 2Phone screening
  3. 3Visit Charleston site if eligible
  4. 4Begin participation

About This Stroke Study in Charleston

Investigators primary aim is to carry out a two-site, randomized, double-blind, sham-controlled, phase II trial to systematically examine the potential for aerobic exercise (AEx) to enhance the anti-depressant benefits of rTMS in individuals with post-stroke depression (PSD). Investigators propose to determine the efficacy of combining two known anti-depressant treatments shown to be effective in non-stroke depression, aerobic exercise (AEx) and repetitive transcranial magnetic stimulation (rTMS), on post-stroke depressive symptoms. This project is based on the idea that depression negatively affects the potential for the brain to adapt in response to treatment such that rehabilitation may not produce the same changes that it does in non-depressed individuals. Investigators believe that effective treatment for PSD will result in a virtuous cycle whereby reducing depression enhances response to rehabilitation, thereby facilitating functional gains. That is, effectively treating depression will enable individuals to better recover from stroke.

Sponsor: Medical University of South Carolina

Who Can Participate

Inclusion Criteria

stroke within the past 12 to 60 months
screen positive for probable major depressive disorder (PHQ-9 \> 10) and HAM-D17 ≥ 14
residual paresis in the lower extremity (Fugl-Meyer LE motor score \<34)
ability to walk without assistance and without an AFO at speeds ranging from 0.2-1.0 m/s
not currently on antidepressant medications or no changes in antidepressant dosage in the last 4 weeks and clinically stable
HAM-D17 question #9 regarding suicide \<2
provision of informed consent.

Exclusion Criteria

unable to ambulate at least 150 feet prior to stroke, or experienced intermittent claudication while walking
history of congestive heart failure, unstable cardiac arrhythmias, hypertrophic cardiomyopathy, severe aortic stenosis, angina or dyspnea at rest or during ADL's
history of COPD or oxygen dependence
history of traumatic brain injury
blindness or severe visual impairment
history of psychosis or other Axis I disorder that is primary
life expectancy \<1 yr.
severe arthritis or problems that limit participation in testing or training
history of DVT or pulmonary embolism within 6 months
uncontrolled diabetes with recent weight loss, diabetic coma, or frequent insulin reactions
severe hypertension with systolic \>200 mmHg and diastolic \>110 mmHg at rest
attempt of suicide in the last 2 years or suicidal risk assessed by SCID
history of seizures or currently prescribed anti-seizure medications
current enrollment in a trial to enhance motor recovery
currently participating in behavioral treatment for depression
currently exercising ≥ 2 times per week (≥20 minutes)
contraindications to TMS
pregnancy or other contraindications to MRI.

Not sure if you qualify? Submit your interest and a study coordinator will help determine your eligibility.

Frequently Asked Questions

Q:Is this study available in Charleston?

Yes, this clinical trial (NCT07050355) has an active research site in Charleston, SC that is currently enrolling participants.

Q:Is it safe to participate?

Clinical trials follow strict safety guidelines and ethical standards. This study has been reviewed and approved, and participants are closely monitored by medical professionals. You can withdraw at any time.

Q:Will I be compensated?

Many clinical trials offer compensation for your time and travel expenses. Specific compensation details will be discussed during the screening process. All study-related medical care is provided at no cost.

Q:Can I leave the trial if I change my mind?

Absolutely. Participation is completely voluntary. You have the right to withdraw from the study at any time, for any reason, without penalty.

Still have questions? Our study coordinators are here to help.

Stroke Treatment Options in Charleston, SC

If you're searching for stroke treatment options in Charleston, SC, this clinical trial (NCT07050355) may be an excellent opportunity. Clinical trials provide access to cutting-edge treatments that aren't yet available to the general public, often at no cost to participants.

Our Charleston research site is actively enrolling participants for this clinical trial. You'll receive care from experienced stroke specialists who are at the forefront of medical research. All study-related care, including examinations, treatments, and monitoring, is provided at no cost to qualified participants.

Looking for more options? Browse all stroke clinical trials near you to find additional studies recruiting in your area.

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Secure · Expert Care · Charleston, SC